Browsing Centers & Institutes by Subject "Systems biology"

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Browsing Centers & Institutes by Subject "Systems biology"

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  • Gyrase Inhibitors Induce an Oxidative Damage Cellular Death Pathway in Escherichia Coli
    Dwyer, Daniel J; Kohanski, Michael A; Hayete, Boris; Collins, James J (2007-03-13)
    Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase ...
  • A Network Biology Approach to Prostate Cancer
    Ergün, Ayla; Lawrence, Carolyn A; Kohanski, Michael A; Brennan, Timothy A; Collins, James J (2007-02-13)
    There is a need to identify genetic mediators of solid-tumor cancers, such as prostate cancer, where invasion and distant metastases determine the clinical outcome of the disease. Whole-genome expression profiling offers ...

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