Browsing Organic Chemistry Laboratory Experiments by Title

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Browsing Organic Chemistry Laboratory Experiments by Title

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  • Grignard Reaction - Synthesis of Substituted Benzoic Acids
    Mulcahy, Seann P. (2011-10-11)
    A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, ...
  • Kinetic Analysis of Ester Hydrolysis
    Mulcahy, Seann P. (2011-07-14)
    A two-week multi-step experiment that introduces students to mechanistic organic chemistry and substituent effects. A simple preparation of differentially substituted para-nitrophenyl benzoates is followed by ester hydrolysis ...
  • Microwave-Assisted Biginelli Reaction
    Mulcahy, Seann P.; Evans, Thomas; Rossi, Lauren (2011-07-14)
    Excellent laboratory procedure for a small focused library of dihydropyrimidinones. Good example of a multicomponent reaction performed using microwave irradiation.
  • Reductive Amination Reaction
    Mulcahy, Seann P. (2011-07-14)
    A simple, solventless procedure for reductive amination that results in an impressive color change. Reaction proceeds in three stages: imine formation, reduction, and acetylation and purification is done by crystallization.
  • Suzuki Cross Coupling
    Mulcahy, Seann P. (2012-01-03)
    An easy preparation of differentially-substituted biaryls is reported by palladium-catalyzed cross coupling. The Suzuki cross coupling reaction is both fast and substituent-independent. Column chromatography is performed ...
  • Wittig Reaction
    Mulcahy, Seann P. (2012-01-03)
    A simple preparation of a conjugated diene via the olefination reaction between cinnamaldehyde and triphenylphosphonium chloride under basic conditions. Students are reintroduced to dry glassware techniques, recrystallization, ...

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