Browsing Organic Chemistry Laboratory Experiments by Issue Date

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Browsing Organic Chemistry Laboratory Experiments by Issue Date

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  • Reductive Amination Reaction
    Mulcahy, Seann P. (2011-07-14)
    A simple, solventless procedure for reductive amination that results in an impressive color change. Reaction proceeds in three stages: imine formation, reduction, and acetylation and purification is done by crystallization.
  • Microwave-Assisted Biginelli Reaction
    Mulcahy, Seann P.; Evans, Thomas; Rossi, Lauren (2011-07-14)
    Excellent laboratory procedure for a small focused library of dihydropyrimidinones. Good example of a multicomponent reaction performed using microwave irradiation.
  • Kinetic Analysis of Ester Hydrolysis
    Mulcahy, Seann P. (2011-07-14)
    A two-week multi-step experiment that introduces students to mechanistic organic chemistry and substituent effects. A simple preparation of differentially substituted para-nitrophenyl benzoates is followed by ester hydrolysis ...
  • Extraction of Caffeine from Energy Drinks
    Mulcahy, Seann P.; Bishop, Joshua (2011-07-14)
    A simple procedure for the isolation of caffeine from energy drinks by solid phase extraction on a C18 cartridge. Quantitative analysis of the amount of caffeine by LC/MS is determined by referencing a standard curve.
  • Grignard Reaction - Synthesis of Substituted Benzoic Acids
    Mulcahy, Seann P. (2011-10-11)
    A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, ...
  • Borohydride Reduction of Fluorenone
    Mulcahy, Seann P. (2011-10-11)
    A simple experiment to demonstrate nucleophilic addition to a carbonyl. Sodium borohydride-mediated reduction of fluorenone is a fast and high-yielding reaction that is suitable for beginning students. Students isolate ...
  • Forensic Analysis of Analgesics by TLC
    Mulcahy, Seann P. (2011-10-15)
    An introductory laboratory on the identification of analgesics in an unknown sample. Ideal for the first week of an organic chemistry sequence to get students familiar with their surroundings. Students extract, isolate, ...
  • Wittig Reaction
    Mulcahy, Seann P. (2012-01-03)
    A simple preparation of a conjugated diene via the olefination reaction between cinnamaldehyde and triphenylphosphonium chloride under basic conditions. Students are reintroduced to dry glassware techniques, recrystallization, ...
  • Suzuki Cross Coupling
    Mulcahy, Seann P. (2012-01-03)
    An easy preparation of differentially-substituted biaryls is reported by palladium-catalyzed cross coupling. The Suzuki cross coupling reaction is both fast and substituent-independent. Column chromatography is performed ...
  • The Asymmetric Aldol Reaction
    Mulcahy, Seann P. (2012-01-03)
    A convenient multi-week experiment that results in the formation of two new stereocenters starting from enantiopure norephedrine as the chiral auxiliary. This experiment uses a variety of purification techniques, including ...
  • Claisen-Schmidt (Aldol) Reaction
    Mulcahy, Seann P. (2012-01-03)
    A short aldol condensation reaction that produces differentially-substituted dibenzylideneketones whose UV-Vis spectra can be determined. This experiment allows students to construct structure-activity relationships in the ...
  • Fisher Esterification: Synthesis of Volatile Esters
    Mulcahy, Seann P. (2012-01-03)
    A microwave-accelerated synthesis of volatile aromatic esters is described in this convenient Fisher esterification reaction. Students perform a liquid-liquid extraction to isolate crude product which they purify by ...

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