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Browsing Molecular Biology, Cell Biology and Biochemistry Program by Author "Collins, James J"

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Gyrase Inhibitors Induce an Oxidative Damage Cellular Death Pathway in Escherichia Coli

Dwyer, Daniel J; Kohanski, Michael A; Hayete, Boris; Collins, James J (2007-03-13)

Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase ...

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