Browsing MED: Medicine Papers by Title

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Browsing MED: Medicine Papers by Title

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  • Porter, Stacy A.; Massaro, Joseph M.; Hoffmann, Udo; Vasan, Ramachandran S.; O'Donnel, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2009-3-5)
    OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN ...
  • Byles, Vanessa; Chmilewski, Laura K.; Wang, Joyce; Zhu, Lijia; Forman, Lora W.; Faller, Douglas V.; Dai, Yan (Ivyspring International Publisher, 2010-10-7)
    SIRT1, an NAD-dependent histone/protein deacetylase, has classically been thought of as a nuclear protein. In this study, we demonstrate that SIRT1 is mainly localized in the nucleus of normal cells, but is predominantly ...
  • Genzen, Jonathan R; Yang, Dan; Ravid, Katya; Bordey, Angelique (BioMed Central, 2009-11-18)
    BACKGROUND: Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system. While ...
  • Kelly, Meghan; Gauthier, Marie-Soleil; Saha, Asish K.; Ruderman, Neil B. (American Diabetes Association, 2009-6-5)
    OBJECTIVE: Interleukin-6 (IL-6) directly activates AMP-activated protein kinase (AMPK) in vivo and in vitro; however, the mechanism by which it does so is unknown. RESEARCH DESIGN AND METHODS: We examined this question in ...
  • Yamin, Rina; Zhao, Cheng; O'Connor, Peter B; McKee, Ann C; Abraham, Carmela R (BioMed Central, 2009-7-23)
    BACKGROUND The abnormal accumulation of amyloid-beta peptide is believed to cause malfunctioning of neurons in the Alzheimer's disease brain. Amyloid-beta exists in different assembly forms in the aging mammalian brain ...
  • Cheng, Susan; Massaro, Joseph M.; Fox, Caroline S.; Larson, Martin G.; Keyes, Michelle J.; McCabe, Elizabeth L.; Robins, Sander J.; O'Donnell, Christopher J.; Hoffmann, Udo; Jacques, Paul F.; Booth, Sarah L.; Vasan, Ramachandran S.; Wolf, Myles; Wang, Thomas J. (American Diabetes Association, 2009-10-15)
    OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical ...
  • Knox, Sarah S.; Guo, Xinxin; Zhang, Yuqing; Weidner, G.; Williams, Scott; Ellison, R. Curtis (Public Library of Science, 2010-10-13)
    BACKGROUND. Both anxiety and elevated heart rate (HR) have been implicated in the development of hypertension. The HyperGen cohort, consisting of siblings with severe and mild hypertension, an age-matched random sample of ...
  • Hahn, Judith A.; Samet, Jeffrey H. (Current Science Inc., 2010-9-3)
    Heavy alcohol use is commonplace among HIV-infected individuals; however, the extent that alcohol use adversely impacts HIV disease progression has not been fully elucidated. Fairly strong evidence suggests that heavy ...
  • Millien, Guetchyn; Spira, Avrum; Hinds, Anne; Wang, Junling; Williams, Mary C; Ramirez, Maria I (BioMed Central, 2006-7-25)
    BACKGROUND. Development of lung alveolar sacs of normal structure and size at late gestation is necessary for the gas exchange process that sustains respiration at birth. Mice lacking the lung differentiation gene T1α ...
  • Chandra, Prakash; Basra, Sukhdeep S.; Chen, Tai C.; Tangpricha, Vin (Hindawi Publishing Corporation, 2010-7-18)
    Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this ...
  • Tao, Rong; Gong, Jun; Luo, Xixi; Zang, Mengwei; Guo, Wen; Wen, Rong; Luo, Zhijun (BioMed Central, 2010-2-18)
    BACKGROUND AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin ...
  • McCracken, John; Baccarelli, Andrea; Hoxha, Mirjam; Dioni, Laura; Melly, Steve; Coull, Brent; Suh, Helen; Vokonas, Pantel; Schwartz, Joel (National Institute of Environmental Health Sciences, 2010-11)
    BACKGROUND. Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE. ...
  • Koido, Shigeo; Homma, Sadamu; Hara, Eiichi; Namiki, Yoshihisa; Ohkusa, Toshifumi; Gong, Jianlin; Tajiri, Hisao (Hindawi Publishing Corporation, 2010-4-7)
    The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation ...
  • Lampe, Brad J.; Park, Sung Kyun; Robins, Thomas; Mukherjee, Bhramar; Litonjua, Augusto A.; Amarasiriwardena, Chitra; Weisskopf, Marc; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2008-09)
    BACKGROUND. High levels of cadmium exposure are known to cause emphysema in occupationally exposed workers, but little has been reported to date on the association between chronic environmental cadmium exposure and pulmonary ...
  • Franklin, Jonas; Englund, Martin; Ingvarsson, Torvaldur; Lohmander, Stefan (BioMed Central, 2010-11-26)
    BACKGROUND: There have been reports both supporting and refuting an inverse relationship between hip fracture and hip osteoarthritis (OA). We explore this relationship using a case-control study design. METHODS: Exclusion ...
  • Franklin, Jonas; Ingvarsson, Thorvaldur; Englund, Martin; Lohmander, Stefan (BioMed Central, 2010-5-24)
    INTRODUCTION. The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS. The following is the case-control ...
  • Kalichman, Leonid; Zhang, Yuqing; Niu, Jingbo; Goggins, Joyce; Gale, Daniel; Zhu, Yanyan; Felson, David T; Hunter, David J (BioMed Central, 2007-3-7)
    The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were recruited to ...
  • Neogi, Tuhina; Felson, David; Niu, Jingbo; Nevitt, Michael; Lewis, Cora E; Aliabadi, Piran; Sack, Burt; Torner, James; Bradley, Lawrence; Zhang, Yuqing (BMJ Publishing Group Ltd., 2009-8-21)
    Objective To examine the relation of radiographic features of osteoarthritis to knee pain in people with knees discordant for knee pain in two cohorts. Design Within person, knee matched, case-control study. Setting and ...
  • Molenaar, Esther A.; Massaro, Joseph M.; Jacques, Paul F.; Pou, Karla M.; Ellison, R. Curtis; Hoffmann, Udo; Pencina, Karol; Shadwick, Steven D.; Vasan, Ramachandran S.; O'Donnell, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: The purpose of this study was to assess the relationship between lifestyle factors and abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in a community-based setting. RESEARCH DESIGN ...
  • Lieb, Wolfgang; Pencina, Michael J.; Lanier, Katherine J.; Tofler, Geoffrey H.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; D'Agostino, Ralph B.; Vasan, Ramachandran S. (American Diabetes Association, 2011-12-29)
    OBJECTIVE: Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence ...

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