Browsing Framingham Heart Study by Issue Date

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Browsing Framingham Heart Study by Issue Date

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  • Genome-Wide Association with Bone Mass and Geometry in the Framingham Heart Study
    Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Genome-Wide Association Study for Subclinical Atherosclerosis in Major Arterial Territories in the NHLBI's Framingham Heart Study
    O'Donnell, Christopher J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Hoffmann, Udo; Hwang, Shih-Jen; Ingellson, Erik; Liu, Chunyu; Murabito, Joanne M; Polak, Joseph F; Wolf, Philip A; Demissie, Serkalem (BioMed Central, 2007-9-19)
    INTRODUCTION: Subclinical atherosclerosis (SCA) measures in multiple arterial beds are heritable phenotypes that are associated with increased incidence of cardiovascular disease. We conducted a genome-wide association ...
  • Genetic Correlates of Longevity and Selected Age-Related Phenotypes: A Genome-Wide Association Study in the Framingham Study
    Lunetta, Kathryn L; D'Agostino, Ralph B; Karasik, David; Benjamin, Emelia J; Guo, Chao-Yu; Govindaraju, Raju; Kiel, Douglas P; Kelly-Hayes, Margaret; Massaro, Joseph M; Pencina, Michael J; Seshadri, Sudha; Murabito, Joanne M (BioMed Central, 2007-9-19)
    BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS: We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) ...
  • Metabolic Profiling of the Human Response to a Glucose Challenge Reveals Distinct Axes of Insulin Sensitivity
    Shaham, Oded; Wei, Ru; Wang, Thomas J; Ricciardi, Catherine; Lewis, Gregory D; Vasan, Ramachandran S; Carr, Steven A; Thadhani, Ravi; Gerszten, Robert E; Mootha, Vamsi K (Nature Publishing GroupMolecular Systems Biology, 2008-08-05)
    Glucose ingestion after an overnight fast triggers an insulin-dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is currently unknown. We ...
  • Plasma Leptin Levels and Incidence of Heart Failure, Cardiovascular Disease, and Total Mortality in Elderly Individuals
    Lieb, Wolfgang; Sullivan, Lisa M.; Harris, Tamara B.; Roubenoff, Ronenn; Benjamin, Emelia J.; Levy, Daniel; Fox, Caroline S.; Wang, Thomas J.; Wilson, Peter W.; Kannel, William B.; Vasan, Ramachandran S. (American Diabetes Association, 2008-12-29)
    OBJECTIVE: Obesity predisposes individuals to congestive heart failure (CHF) and cardiovascular disease (CVD). Leptin regulates energy homeostasis, is elevated in obesity, and influences ventricular and vascular remodeling. ...
  • Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
    Kimura, Masayuki; Cherkas, Lynn F; Kato, Bernet S; Demissie, Serkalem; Hjelmborg, Jacob B; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L; Gardner, Jefferey P; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A; Hunt, Steven C; Christensen, Kaare; Levy, Daniel; Spector, Tim D; Aviv, Abraham (Public Library of Science, 2008-2-15)
    Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We ...
  • Genome-Wide Association Study for Renal Traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
    Kottgen, Anna; Kao, Wen Hong L; Hwang, Shih-Jen; Boerwinkle, Eric; Yang, Qiong; Levy, Daniel; Benjamin, Emelia J; Larson, Martin G; Astor, Brad C; Coresh, Josef; Fox, Caroline S (BioMed Central, 2008-6-3)
    BACKGROUND: The Framingham Heart Study (FHS) recently obtained initial results from the first genome-wide association scan for renal traits. The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants ...
  • Adiposity, Cardiometabolic Risk, and Vitamin D Status: The Framingham Heart Study
    Cheng, Susan; Massaro, Joseph M.; Fox, Caroline S.; Larson, Martin G.; Keyes, Michelle J.; McCabe, Elizabeth L.; Robins, Sander J.; O'Donnell, Christopher J.; Hoffmann, Udo; Jacques, Paul F.; Booth, Sarah L.; Vasan, Ramachandran S.; Wolf, Myles; Wang, Thomas J. (American Diabetes Association, 2009-10-15)
    OBJECTIVE: Because vitamin D deficiency is associated with a variety of chronic diseases, understanding the characteristics that promote vitamin D deficiency in otherwise healthy adults could have important clinical ...
  • Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis
    Chasman, Daniel I.; Paré, Guillaume; Mora, Samia; Hopewell, Jemma C.; Peloso, Gina; Clarke, Robert; Cupples, L. Adrienne; Hamsten, Anders; Kathiresan, Sekar; Mälarstig, Anders; Ordovas, José M.; Ripatti, Samuli; Parker, Alex N.; Miletich, Joseph P.; Ridker, Paul M. (Public Library of Science, 2009-11-20)
    While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more accurately reflect lipoprotein particle concentrations according to ...
  • On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies
    Won, Sungho; Wilk, Jemma B.; Mathias, Rasika A.; O'Donnell, Christopher J.; Silverman, Edwin K.; Barnes, Kathleen; O'Connor, George T.; Weiss, Scott T.; Lange, Christoph (Public Library of Science, 2009-11-26)
    For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ...
  • Incorporating Biological Knowledge in the Search for Gene × Gene Interaction in Genome-Wide Association Studies
    Manning, Alisa K; Ngwa, Julius Suh; Hendricks, Audrey E; Liu, Ching-Ti; Johnson, Andrew D; Dupuis, Josée; Cupples, L Adrienne (BioMed Central, 2009-12-15)
    We sought to find significant gene × gene interaction in a genome-wide association analysis of rheumatoid arthritis (RA) by performing pair-wise tests of interaction among collections of single-nucleotide polymorphisms ...
  • Genetics Analysis Workshop 16 Problem 2: tTe Framingham Heart Study Data
    Cupples, L Adrienne; Heard-Costa, Nancy; Lee, Monica; Atwood, Larry D (BioMed Central, 2009-12-15)
    Genetic Analysis Workshop 16 (GAW16) Problem 2 presented data from the Framingham Heart Study (FHS), an observational, prospective study of risk factors for cardiovascular disease begun in 1948. Data have been collected ...
  • Genetic Analysis Workshop 16: Strategies for Genome-Wide Association Study Analyses
    Cupples, L Adrienne; Beyene, Joseph; Bickeböller, Heike; Daw, E Warwick; Fallin, M Daniele; Gauderman, W James; Ghosh, Saurabh; Goode, Ellen L; Hauser, Elizabeth R; Hinrichs, Anthony; Kent, Jack W; Martin, Lisa J; Martinez, Maria; Neuman, Rosalind J; Province, Michael; Szymczak, Silke; Wilcox, Marsha A; Ziegler, Andreas; MacCluer, Jean W; Almasy, Laura (BioMed Central, 2009-12-15)
  • Cross-Sectional Associations Bet ween Abdominal and Thoracic Adipose Tissue Compartments and Adiponectin and Resistin in the Framingham Heart Study
    Jain, Shilpa H.; Massaro, Joseph M.; Hoffmann, Udo; Rosito, Guido A.; Vasan, Ramachandran S.; Raji, Annaswamy; O'Donnell, Christopher J.; Meigs, James B.; Fox, Caroline S. (American Diabetes Association, 2009-2-17)
    OBJECTIVE: To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and ...
  • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study
    Wilk, Jemma B.; Chen, Ting-hsu; Gottlieb, Daniel J.; Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Myers, Richard H.; Borecki, Ingrid B.; Silverman, Edwin K.; Weiss, Scott T.; O'Connor, George T. (Public Library of Science, 2009-3-20)
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...
  • Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?
    Porter, Stacy A.; Massaro, Joseph M.; Hoffmann, Udo; Vasan, Ramachandran S.; O'Donnel, Christopher J.; Fox, Caroline S. (American Diabetes Association, 2009-3-5)
    OBJECTIVE: Obesity is associated with increased metabolic and cardiovascular risk. The ectopic fat hypothesis suggests that subcutaneous fat may be protective, but this theory has yet to be fully explored. RESEARCH DESIGN ...
  • NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
    Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • Efficacy of Dietary Behavior Modification for Preserving Cardiovascular Health and Longevity
    Pryde, Moira McAllister; Kannel, William Bernard (SAGE-Hindawi Access to Research, 2010-12-28)
    Cardiovascular disease (CVD) and its predisposing risk factors are major lifestyle and behavioral determinants of longevity. Dietary lifestyle choices such as a heart healthy diet, regular exercise, a lean weight, moderate ...
  • Interpreting Metabolomic Profiles using Unbiased Pathway Models
    Deo, Rahul C.; Hunter, Luke; Lewis, Gregory D.; Pare, Guillaume; Vasan, Ramachandran S.; Chasman, Daniel; Wang, Thomas J.; Gerszten, Robert E.; Roth, Frederick P. (Public Library of Science, 2010-2-26)
    Human disease is heterogeneous, with similar disease phenotypes resulting from distinct combinations of genetic and environmental factors. Small-molecule profiling can address disease heterogeneity by evaluating the ...
  • A Three-Stage Approach for Genome-Wide Association Studies with Family Data for Quantitative Traits
    Chen, Ming-Huei; Larson, Martin G; Hsu, Yi-Hsiang; Peloso, Gina M; Guo, Chao-Yu; Fox, Caroline S; Atwood, Larry D; Yang, Qiong (BioMed Central, 2010-5-14)
    BACKGROUND. Genome-wide association (GWA) studies that use population-based association approaches may identify spurious associations in the presence of population admixture. In this paper, we propose a novel three-stage ...

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