Evidence for a Gene Influencing Heart Rate on Chromosome 5P13-14 in a Meta-Analysis of Genome-Wide Scans from the NHLBI Family Blood Pressure Program

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dc.contributor.author Laramie, Jason M en_US
dc.contributor.author Wilk, Jemma B en_US
dc.contributor.author Hunt, Steven C en_US
dc.contributor.author Ellison, R Curtis en_US
dc.contributor.author Chakravarti, Aravinda en_US
dc.contributor.author Boerwinkle, Eric en_US
dc.contributor.author Myers, Richard H en_US
dc.date.accessioned 2011-12-29T21:02:16Z
dc.date.available 2011-12-29T21:02:16Z
dc.date.copyright 2006 en_US
dc.date.issued 2006-3-1 en_US
dc.identifier.citation Laramie, Jason M, Jemma B Wilk, Steven C Hunt, R Curtis Ellison, Aravinda Chakravarti, Eric Boerwinkle, Richard H Myers. "Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program." BMC Medical Genetics 7:17. (2006) en_US
dc.identifier.issn 1471-2350 en_US
dc.identifier.uri http://hdl.handle.net/2144/2499
dc.description.abstract BACKGROUND: Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic linkage scans to identify quantitative trait loci. METHODS: We performed a genome-wide linkage scan to identify quantitative trait loci influencing resting heart rate among 3,282 Caucasians and 3,989 African-Americans in three independent networks comprising the Family Blood Pressure Program (FBPP) using 368 microsatellite markers. Mean heart rate measurements were used in a regression model including covariates for age, body mass index, pack-years, currently drinking alcohol (yes/no), hypertension status and medication usage to create a standardized residual for each gender/ethnic group within each study network. This residual was used in a nonparametric variance component model to generate a LOD score and a corresponding P value for each ethnic group within each study network. P values from each ethnic group and study network were merged using an adjusted Fisher's combining P values method and the resulting P values were converted to LOD scores. The entire analysis was redone after individuals currently taking beta-blocker medication were removed. RESULTS: We identified significant evidence of linkage (LOD = 4.62) to chromosome 10 near 142.78 cM in the Caucasian group of HyperGEN. Between race and network groups we identified a LOD score of 1.86 on chromosome 5 (between 39.99 and 45.34 cM) in African-Americans in the GENOA network and the same region produced a LOD score of 1.12 among Caucasians within a different network (HyperGEN). Combining all network and race groups we identified a LOD score of 1.92 (P = 0.0013) on chromosome 5p13-14. We assessed heterogeneity for this locus between networks and ethnic groups and found significant evidence for low heterogeneity (P ≤ 0.05). CONCLUSION: We found replication (LOD > 1) between ethnic groups and between study networks with low heterogeneity on chromosome 5p13-14 suggesting that a gene in this region influences resting heart rate. en_US
dc.description.sponsorship National Heart, Lung, and Blood Institute (GenNEt HL45508, HL47910, GENOA R01 HL51021, U10 HL54481, HL54464, HyperGEN, HL54473, HL54496, HL54472, HL54515, HL54495, HL54497, HL54471, HL54509) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2006 Laramie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Evidence for a Gene Influencing Heart Rate on Chromosome 5P13-14 in a Meta-Analysis of Genome-Wide Scans from the NHLBI Family Blood Pressure Program en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2350-7-17 en_US
dc.identifier.pubmedid 16509988 en_US
dc.identifier.pmcid 1413518 en_US

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