The Relation of C - Reactive Protein to Chronic Kidney Disease in African Americans: The Jackson Heart Study

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dc.contributor.author Fox, Ervin R en_US
dc.contributor.author Benjamin, Emelia J en_US
dc.contributor.author Sarpong, Daniel F en_US
dc.contributor.author Nagarajarao, Harsha en_US
dc.contributor.author Taylor, Jason K en_US
dc.contributor.author Steffes, Michael W en_US
dc.contributor.author Salahudeen, Abdullah K en_US
dc.contributor.author Flessner, Michael F en_US
dc.contributor.author Akylbekova, Ermeg L en_US
dc.contributor.author Fox, Caroline S en_US
dc.contributor.author Garrison, Robert J en_US
dc.contributor.author Taylor, Herman A en_US
dc.date.accessioned 2011-12-29T21:02:24Z
dc.date.available 2011-12-29T21:02:24Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-1-15 en_US
dc.identifier.citation Fox, Ervin R, Emelia J Benjamin, Daniel F Sarpong, Harsha Nagarajarao, Jason K Taylor, Michael W Steffes, Abdullah K Salahudeen, Michael F Flessner, Ermeg L Akylbekova, Caroline S Fox, Robert J Garrison, Herman A Taylor. "The relation of C - reactive protein to chronic kidney disease in African Americans: the Jackson Heart Study" BMC Nephrology 11:1. (2010) en_US
dc.identifier.issn 1471-2369 en_US
dc.identifier.uri http://hdl.handle.net/2144/2523
dc.description.abstract BACKGROUND: African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD - estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. Inflammation has been related to renal disease in non-Hispanic whites, but there are limited data on the role of inflammation in renal dysfunction in African Americans in the community. METHODS: We examined the cross-sectional relation of log transformed C-reactive protein (CRP) to renal function (eGFR by Modification of Diet and Renal Disease equation) in African American participants of the community-based Jackson Heart Study's first examination (2000 to 2004). We conducted multivariable linear regression relating CRP to eGFR adjusting for age, sex, body mass index, systolic and diastolic blood pressure, diabetes, total/HDL cholesterol, triglycerides, smoking, antihypertensive therapy, lipid lowering therapy, hormone replacement therapy, and prevalent cardiovascular disease events. In a secondary analysis we assessed the association of CRP with albuminuria (defined as albumin-to-creatinine ratio > 30 mg/g). RESULTS: Participants (n = 4320, 63.2% women) had a mean age ± SD of 54.0 ± 12.8 years. The prevalence of CKD was 5.2% (n = 228 cases). In multivariable regression, CRP concentrations were higher in those with CKD compared to those without CKD (mean CRP 3.2 ± 1.1 mg/L vs. 2.4 ± 1.0 mg/L, respectively p < 0.0001). CRP was significantly associated with albuminuria in sex and age adjusted model however not in the multivariable adjusted model (p > 0.05). CONCLUSION: CRP was associated with CKD however not albuminuria in multivariable-adjusted analyses. The study of inflammation in the progression of renal disease in African Americans merits further investigation. en_US
dc.description.sponsorship National Institutes of Health (N01-HC-95170, N01-HC-95171, N01-HC-95172); National Heart, Lung, and Blood Institute (HL067784); National Center for Minority Health and Health Disparities; National Institute of Aging (AG028321) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Fox et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title The Relation of C - Reactive Protein to Chronic Kidney Disease in African Americans: The Jackson Heart Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2369-11-1 en_US
dc.identifier.pubmedid 20078870 en_US
dc.identifier.pmcid 2826325 en_US

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