Genetic Analysis of the GRIK2 Modifier Effect in Huntington's Disease


Show simple item record Zeng, Wenqi en_US Gillis, Tammy en_US Hakky, Michael en_US Djoussé, Luc en_US Myers, Richard H en_US MacDonald, Marcy E en_US Gusella, James F en_US 2011-12-29T21:02:24Z 2011-12-29T21:02:24Z 2006 en_US 2006-9-7 en_US
dc.identifier.citation Zeng, Wenqi, Tammy Gillis, Michael Hakky, Luc Djoussé, Richard H Myers, Marcy E MacDonald, James F Gusella. "Genetic analysis of the GRIK2 modifier effect in Huntington's disease" BMC Neuroscience 7:62. (2006) en_US
dc.identifier.issn 1471-2202 en_US
dc.description.abstract BACKGROUND: In Huntington's disease (HD), age at neurological onset is inversely correlated with the length of the CAG trinucleotide repeat mutation, but can be modified by genetic factors beyond the HD gene. Association of a relatively infrequent 16 TAA allele of a trinucleotide repeat polymorphism in the GRIK2 3'UTR with earlier than expected age at neurological onset has been suggested to reflect linkage disequilibrium with a functional polymorphism in GRIK2 or an adjacent gene. RESULTS: We have tested this hypothesis by sequencing all GRIK2 exons, the exon-flanking sequences and 3'UTR in several individuals who were crucial to demonstrating the modifier effect, as they showed much earlier age at neurological onset than would be expected from the length of their HD CAG mutation. Though ten known SNPs were detected, no sequence variants were found in coding or adjacent sequence that could explain the modifier effect by linkage disequilibrium with the 16 TAA allele. Haplotype analysis using microsatellites, known SNPs and new variants discovered in the 3'UTR argues against a common ancestral origin for the 16 TAA repeat alleles in these individuals. CONCLUSION: These data suggest that the modifier effect is actually due to the TAA repeat itself, possibly via a functional consequence on the GRIK2 mRNA. en_US
dc.description.sponsorship US Public Health Service (NS16367); Huntington Disease Society of America's Coalition for the Cure; Harvard Center for Neurodegeneration and Repair en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2006 Zeng et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title Genetic Analysis of the GRIK2 Modifier Effect in Huntington's Disease en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2202-7-62 en_US
dc.identifier.pubmedid 16959037 en_US
dc.identifier.pmcid 1618398 en_US

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