Risk Factors for Negative Blood Cultures in Adult Medical Inpatients – a Retrospective Analysis

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dc.contributor.author Ehrenstein, Boris P en_US
dc.contributor.author Ehrenstein, Vera en_US
dc.contributor.author Henke, Christine en_US
dc.contributor.author Linde, Hans-Jörg en_US
dc.contributor.author Salzberger, Bernd en_US
dc.contributor.author Schölmerich, Jürgen en_US
dc.contributor.author Glück, Thomas en_US
dc.date.accessioned 2011-12-29T22:39:39Z
dc.date.available 2011-12-29T22:39:39Z
dc.date.copyright 2008 en_US
dc.date.issued 2008-10-28 en_US
dc.identifier.citation Ehrenstein, Boris P, Vera Ehrenstein, Christine Henke, Hans-Jörg Linde, Bernd Salzberger, Jürgen Schölmerich, Thomas Glück. "Risk factors for negative blood cultures in adult medical inpatients – a retrospective analysis." BMC Infectious Diseases8:148. (2008) en_US
dc.identifier.issn 1471-2334 en_US
dc.identifier.uri http://hdl.handle.net/2144/2585
dc.description.abstract BACKGROUND: The identification of clinical factors associated with negative blood cultures could help to avoid unnecessary blood cultures. C-reactive protein (CRP) is a well-established inflammation marker commonly used in the management of medical inpatients. METHODS: We studied the association of clinical factors, CRP levels and changes of CRP documented prior to blood culture draws with the absence of bacteremia for hospitalized medical patients. RESULTS: In the retrospective analysis of 710 blood cultures obtained from 310 medical inpatients of non-intensive-care wards during one year (admission blood cultures obtained in the emergency room were excluded), the following retrospectively available factors were the only independent predictors of blood cultures negative for obligate pathogens: a good clinical condition represented by the lowest of three general nursing categories (OR 4.2, 95% CI 1.8 – 9.5), a CRP rise > 50 mg/L documented before the blood culture draw (OR 2.0 95% CI 1.8–9.5) and any antibiotic treatment in the previous seven days (OR 2.0, 95% CI 1.1–3.5). CONCLUSION: Including the general clinical condition, antibiotic pre-treatment and a substantial rise of CRP into the decision, whether or not to obtain blood cultures from medical inpatients with a suspected infection, could improve the diagnostic yield. en_US
dc.description.sponsorship Department of Internal Medicine, University of Regensburg, Germany en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2008 Ehrenstein et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Risk Factors for Negative Blood Cultures in Adult Medical Inpatients – a Retrospective Analysis en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2334-8-148 en_US
dc.identifier.pubmedid 18957115 en_US
dc.identifier.pmcid 2582035 en_US

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