Retrivability in The Danish National Hospital Registry of HIV and Hepatitis B and C Coinfection Diagnoses of Patients Managed in HIV Centers 1995–2004


Show simple item record Obel, Niels en_US Reinholdt, Hanne en_US Omland, Lars H en_US Engsig, Frederik en_US Sørensen, Henrik T en_US Hansen, Ann-Brit E en_US 2011-12-29T22:39:39Z 2011-12-29T22:39:39Z 2008 en_US 2008-4-25 en_US
dc.identifier.citation Obel, Niels, Hanne Reinholdt, Lars H Omland, Frederik Engsig, Henrik T Sørensen, Ann-Brit E Hansen. "Retrivability in The Danish National Hospital Registry of HIV and hepatitis B and C coinfection diagnoses of patients managed in HIV centers 1995–2004" BMC Medical Research Methodology 8:25. (2008) en_US
dc.identifier.issn 1471-2288 en_US
dc.description.abstract BACKGROUND: Hospital-based discharge registries are used increasingly for longitudinal epidemiological studies of HIV. We examined completeness of registration of HIV infections and of chronic hepatitis B (HBV) and hepatitis C (HCV) coinfections in the Danish National Hospital Registry (DNHR) covering all Danish hospitals. METHODS: The Danish HIV Cohort Study (DHCS) encompasses all HIV-infected patients treated in Danish HIV clinics since 1 January 1995. All 2,033 Danish patients in DHCS diagnosed with HIV-1 during the 10-year period from 1 January 1995 to 31 December 2004 were included in the current analysis. We used the DHCS as a reference to examine the completeness of HIV and of HBV and HCV coinfections recorded in DNHR. Cox regression analysis was used to estimate hazard ratios of time to diagnosis of HIV in DNHR compared to DHCS. RESULTS: Of the 2,033 HIV patients in DHCS, a total of 2,006 (99%) were registered with HIV in DNHR. Of these, 1,888 (93%) were registered in DNHR within one year of their first positive HIV test. A CD4 < 200 cells/μl, a viral load >= 100,000 copies/ml and being diagnosed after 1 January 2000, were associated with earlier registration in DNHR, both in crude and adjusted analyses. Thirty (23%) HIV patients registered with chronic HBV (n = 129) in DHCS and 126 (48%) of HIV patients with HCV (n = 264) in DHCS were registered with these diagnoses in the DNHR. Further 17 and 8 patients were registered with HBV and HCV respectively in DNHR, but not in DHCS. The positive predictive values of being registered with HBV and HCV in DHCS were thereby estimated to 0.88 and 0.97 and in DNHR to 0.32 and 0.54. CONCLUSION: The study demonstrates that secondary data from national hospital databases may be reliable for identification of patients diagnosed with HIV infection. However, the predictive value of co-morbidity data may be low. en_US
dc.description.sponsorship Roche; Bristol-Myers Squibb; Merck Sharp and Dohme; GlaxoSmithKline; Abbott; Boehringer Ingelheim; Janssen-Cilag; Swedish Orphan en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2008 Obel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title Retrivability in The Danish National Hospital Registry of HIV and Hepatitis B and C Coinfection Diagnoses of Patients Managed in HIV Centers 1995–2004 en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2288-8-25 en_US
dc.identifier.pubmedid 18439245 en_US
dc.identifier.pmcid 2386497 en_US

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