Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes

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dc.contributor.author Ficociello, Linda H. en_US
dc.contributor.author Perkins, Bruce A. en_US
dc.contributor.author Roshan, Bijan en_US
dc.contributor.author Weinberg, Janice M. en_US
dc.contributor.author Aschengrau, Ann en_US
dc.contributor.author Warram, James H. en_US
dc.contributor.author Krolewski, Andrzej S. en_US
dc.date.accessioned 2011-12-29T22:41:32Z
dc.date.available 2011-12-29T22:41:32Z
dc.date.issued 2009-2-5 en_US
dc.identifier.citation Ficociello, Linda H., Bruce A. Perkins, Bijan Roshan, Janice M. Weinberg, Ann Aschengrau, James H. Warram, Andrzej S. Krolewski. "Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes" Diabetes Care 32(5): 889-893. (2009) en_US
dc.identifier.issn 1935-5548 en_US
dc.identifier.uri http://hdl.handle.net/2144/2596
dc.description.abstract OBJECTIVE: The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk factors. RESEARCH DESIGN AND METHODS: The study group comprised 426 participants with normoalbuminuria from the First Joslin Kidney Study, followed for 15 years. Glomerular filtration rate was estimated by serum cystatin C, and hyperfiltration was defined as exceeding the 97.5th percentile of the sex-specific distribution of a similarly aged, nondiabetic population (134 and 149 ml/min per 1.73 m2 for men and women, respectively). The outcome was time to microalbuminuria development (multiple albumin excretion rate >30 μg/min). Hazard ratios (HRs) for microalbuminuria were calculated at 5, 10, and 15 years. RESULTS: Renal hyperfiltration was present in 24% of the study group and did not increase the risk of developing microalbuminuria. The unadjusted HR for microalbuminuria comparing those with and without hyperfiltration at baseline was 0.8 (95% CI 0.4–1.7) during the first 5 years, 1.0 (0.6–1.7) during the first 10 years, and 0.8 (0.5–1.4) during 15 years of follow-up. The model adjusted for baseline known risk factors including A1C, age at diagnosis of diabetes, diabetes duration, and cigarette smoking resulted in similar HRs. In addition, incorporating changes in hyperfiltration status during follow-up had minimal impact on the HRs for microalbuminuria. CONCLUSION;S Renal hyperfiltration does not have an impact on the development of microalbuminuria in type 1 diabetes during 5, 10, or 15 years of follow-up. en_US
dc.description.sponsorship National Institutes of Health Grant (DK 041526) en_US
dc.language.iso en en_US
dc.publisher American Diabetes Association en_US
dc.title Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes en_US
dc.type article en_US
dc.identifier.doi 10.2337/dc08-1560 en_US
dc.identifier.pubmedid 19196883 en_US
dc.identifier.pmcid 2671109 en_US

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