Impact of Tetrachloroethylene-Contaminated Drinking Water on the Risk of Breast Cancer: Using a Dose Model to Assess Exposure in a Case-Control Study

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dc.contributor.author Vieira, Verónica en_US
dc.contributor.author Aschengrau, Ann en_US
dc.contributor.author Ozonoff, David en_US
dc.date.accessioned 2011-12-29T22:41:32Z
dc.date.available 2011-12-29T22:41:32Z
dc.date.copyright 2005 en_US
dc.date.issued 2005-2-25 en_US
dc.identifier.citation Vieira, Verónica, Ann Aschengrau, David Ozonoff. "Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: Using a dose model to assess exposure in a case-control study" Environmental Health 4:3. (2005) en_US
dc.identifier.issn 1476-069X en_US
dc.identifier.uri http://hdl.handle.net/2144/2597
dc.description.abstract BACKGROUND: A population-based case-control study was undertaken in 1997 to investigate the association between tetrachloroethylene (PCE) exposure from public drinking water and breast cancer among permanent residents of the Cape Cod region of Massachusetts. PCE, a volatile organic chemical, leached from the vinyl lining of certain water distribution pipes into drinking water from the late 1960s through the early 1980s. The measure of exposure in the original study, referred to as the relative delivered dose (RDD), was based on an amount of PCE in the tap water entering the home and estimated with a mathematical model that involved only characteristics of the distribution system. METHODS: In the current analysis, we constructed a personal delivered dose (PDD) model that included personal information on tap water consumption and bathing habits so that inhalation, ingestion, and dermal absorption were also considered. We reanalyzed the association between PCE and breast cancer and compared the results to the original RDD analysis of subjects with complete data. RESULTS: The PDD model produced higher adjusted odds ratios than the RDD model for exposures > 50th and >75th percentile when shorter latency periods were considered, and for exposures < 50th and >90th percentile when longer latency periods were considered. Overall, however, the results from the PDD analysis did not differ greatly from the RDD analysis. CONCLUSION: The inputs that most heavily influenced the PDD model were initial water concentration and duration of exposure. These variables were also included in the RDD model. In this study population, personal factors like bath and shower temperature, bathing frequencies and durations, and water consumption did not differ greatly among subjects, so including this information in the model did not significantly change subjects' exposure classification. en_US
dc.description.sponsorship National Institute of Environmental Health Sciences (2P42 ES07381); United States Environmental Protection Agency en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2005 Vieira et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution 2.0 License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Impact of Tetrachloroethylene-Contaminated Drinking Water on the Risk of Breast Cancer: Using a Dose Model to Assess Exposure in a Case-Control Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1476-069X-4-3 en_US
dc.identifier.pubmedid 15733317 en_US
dc.identifier.pmcid 554766 en_US

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