Dwyer, Daniel J; Kohanski, Michael A; Hayete, Boris; Collins, James J(2007-03-13)
Modulation of bacterial chromosomal supercoiling is a function of DNA gyrase-catalyzed strand breakage and rejoining. This reaction is exploited by both antibiotic and proteic gyrase inhibitors, which trap the gyrase ...
Ergün, Ayla; Lawrence, Carolyn A; Kohanski, Michael A; Brennan, Timothy A; Collins, James J(2007-02-13)
There is a need to identify genetic mediators of solid-tumor cancers, such as prostate cancer, where invasion and distant metastases determine the clinical outcome of the disease. Whole-genome expression profiling offers ...
