Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12-15 Years of Age


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dc.contributor.author Hoffman, Kate en_US
dc.contributor.author Webster, Thomas F. en_US
dc.contributor.author Weisskopf, Marc G. en_US
dc.contributor.author Weinberg, Janice en_US
dc.contributor.author Vieira, Verónica M. en_US
dc.date.accessioned 2012-01-09T14:34:18Z
dc.date.available 2012-01-09T14:34:18Z
dc.date.issued 2010-12 en_US
dc.identifier.citation Hoffman, Kate, Thomas F. Webster, Marc G. Weisskopf, Janice Weinberg, Verónica M. Vieira. "Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12-15 Years of Age" Environmental Health Perspectives 118 (12): 1762-1767. (2010) en_US
dc.identifier.issn 1552-9924 en_US
dc.identifier.uri http://hdl.handle.net/2144/2777
dc.description.abstract BACKGROUND. Polyfluoroalkyl chemicals (PFCs) have been widely used in consumer products. Exposures in the United States and in world populations are widespread. PFC exposures have been linked to various health impacts, and data in animals suggest that PFCs may be potential developmental neurotoxicants. OBJECTIVES. We evaluated the associations between exposures to four PFCs and parental report of diagnosis of attention deficit/hyperactivity disorder (ADHD). METHODS. Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2003-2004 for children 12-15 years of age. Parental report of a previous diagnosis by a doctor or health care professional of ADHD in the child was the primary outcome measure. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS) levels were measured in serum samples from each child. RESULTS. Parents reported that 48 of 571 children included in the analysis had been diagnosed with ADHD. The adjusted odds ratio (OR) for parentally reported ADHD in association with a 1-μg/L increase in serum PFOS (modeled as a continuous predictor) was 1.03 [95% confidence interval (CI), 1.01-1.05]. Adjusted ORs for 1-μg/L increases in PFOA and PFHxS were also statistically significant (PFOA: OR = 1.12; 95% CI, 1.01-1.23; PFHxS: OR = 1.06; 95% CI, 1.02-1.11), and we observed a nonsignificant positive association with PFNA (OR = 1.32; 95% CI, 0.86-2.02). CONCLUSIONS. Our results, using cross-sectional data, are consistent with increased odds of ADHD in children with higher serum PFC levels. Given the extremely prevalent exposure to PFCs, follow-up of these data with cohort studies is needed. en_US
dc.language.iso en en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.rights This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. en_US
dc.subject Attention deficit/hyperactivity disorder (ADHD) en_US
dc.subject National Health and Nutrition Examination Survey (NHANES) en_US
dc.subject Perfluorohexane sulfonic acid (PFHxS) en_US
dc.subject Perfluorononanoic acid (PFNA) en_US
dc.subject Perfluorooctane sulfonic acid (PFOS) en_US
dc.subject Perfluorooctanoic acid (PFOA) en_US
dc.subject Polyfluoroalkyl chemicals (PFCs) en_US
dc.title Exposure to Polyfluoroalkyl Chemicals and Attention Deficit/Hyperactivity Disorder in U.S. Children 12-15 Years of Age en_US
dc.type article en_US
dc.identifier.doi 10.1289/ehp.1001898 en_US
dc.identifier.pubmedid 20551004 en_US
dc.identifier.pmcid 3002197 en_US

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