Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network

dc.contributor.author	Linghu, Bolan	en_US
dc.contributor.author	Snitkin, Evan S	en_US
dc.contributor.author	Hu, Zhenjun	en_US
dc.contributor.author	Xia, Yu	en_US
dc.contributor.author	DeLisi, Charles	en_US
dc.date.accessioned	2012-01-09T14:44:43Z
dc.date.available	2012-01-09T14:44:43Z
dc.date.copyright	2009	en_US
dc.date.issued	2009-09-03	en_US
dc.identifier.citation	Linghu, Bolan, Evan S Snitkin, Zhenjun Hu, Yu Xia, Charles DeLisi. "Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network" Genome Biology 10(9):R91. (2009)	en_US
dc.identifier.issn	1465-6914	en_US
dc.identifier.uri	http://hdl.handle.net/2144/2786
dc.description.abstract	An evidence-weighted functional-linkage network of human genes reveals associations among diseases that share no known disease genes and have dissimilar phenotypes. We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phenotypes, such as hypercholesterolemia and Alzheimer's disease. Many of these disease-disease associations are supported by epidemiology, but with no previous genetic basis. Such associations can drive novel hypotheses on molecular mechanisms of diseases and therapies.	en_US
dc.description.sponsorship	National Institutes of Health (R01 RR022971); RhRMA Foundation (Research Starter Grant)	en_US
dc.language.iso	en	en_US
dc.publisher	BioMed Central	en_US
dc.rights	Copyright 2009 Linghu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en_US
dc.rights.uri	http://creativecommons.org/licenses/by/2.0	en_US
dc.title	Genome-Wide Prioritization of Disease Genes and Identification of Disease-Disease Associations from an Integrated Human Functional Linkage Network	en_US
dc.type	article	en_US
dc.identifier.doi	10.1186/gb-2009-10-9-r91	en_US
dc.identifier.pubmedid	19728866	en_US
dc.identifier.pmcid	2768980	en_US