Identification of Functional Modules That Correlate with Phenotypic Difference: The Influence of Network Topology

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dc.contributor.author Hung, Jui-Hung en_US
dc.contributor.author Whitfield, Troy W en_US
dc.contributor.author Yang, Tun-Hsiang en_US
dc.contributor.author Hu, Zhenjun en_US
dc.contributor.author Weng, Zhiping en_US
dc.contributor.author DeLisi, Charles en_US
dc.date.accessioned 2012-01-09T14:44:44Z
dc.date.available 2012-01-09T14:44:44Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-02-26 en_US
dc.identifier.citation Hung, Jui-Hung, Troy W Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, Charles DeLisi. "Identification of Functional Modules That Correlate with Phenotypic Difference: The Influence of Network Topology" Genome Biology 11(2):R23. (2010) en_US
dc.identifier.issn 1465-6914 en_US
dc.identifier.uri http://hdl.handle.net/2144/2787
dc.description.abstract A gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis. en_US
dc.description.sponsorship National Institutes of Health (HG004561, GM080625,RR022971, DA19362) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Hung et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Identification of Functional Modules That Correlate with Phenotypic Difference: The Influence of Network Topology en_US
dc.type article en_US
dc.identifier.doi 10.1186/gb-2010-11-2-r23 en_US
dc.identifier.pubmedid 20187943 en_US
dc.identifier.pmcid 2872883 en_US

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