Working Memory Performance Correlates with Prefrontal-Hippocampal Theta Interactions but not with Prefrontal Neuron Firing Rates

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dc.contributor.author Hyman, James M. en_US
dc.contributor.author Zilli, Eric A. en_US
dc.contributor.author Paley, Amanda M. en_US
dc.contributor.author Hasselmo, Michael E. en_US
dc.date.accessioned 2012-01-09T15:01:06Z
dc.date.available 2012-01-09T15:01:06Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-03-10 en_US
dc.identifier.citation Hyman, James M., Eric A. Zilli, Amanda M. Paley, Michael E. Hasselmo. "Working Memory Performance Correlates with Prefrontal-Hippocampal Theta Interactions but Not with Prefrontal Neuron Firing Rates" Frontiers in Integrative Neuroscience 4 (2010) en_US
dc.identifier.issn 1662-5145 en_US
dc.identifier.uri http://hdl.handle.net/2144/2804
dc.description.abstract Performance of memory tasks is impaired by lesions to either the medial prefrontal cortex (mPFC) or the hippocampus (HPC); although how these two areas contribute to successful performance is not well understood. mPFC unit activity is temporally affected by hippocampal-theta oscillations, with almost half the mPFC population entrained to theta in behaving animals, pointing to theta interactions as the mechanism enabling collaborations between these two areas. mPFC neurons respond to sensory stimuli and responses in working memory tasks, though the function of these correlated firing rate changes remains unclear because similar responses are reported during mPFC dependent and independent tasks. Using a DNMS task we compared error trials vs. correct trials and found almost all mPFC cells fired at similar rates during both error and correct trials (92%), however theta-entrainment of mPFC neurons declined during error performance as only 17% of cells were theta-entrained (during correct trials 46% of the population was theta-entrained). Across the population, error and correct trials did not differ in firing rate, but theta-entrainment was impaired. Periods of theta-entrainment and firing rate changes appeared to be independent variables, and only theta-entrainment was correlated with successful performance, indicating mPFC-HPC theta-range interactions are the key to successful DNMS performance. en_US
dc.language.iso en en_US
dc.publisher Frontiers Research Foundation en_US
dc.rights Copyright 2010 Hyman, Zilli, Paley and Hasselmo. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. en_US
dc.rights.uri http://www.frontiersin.org/licenseagreement en_US
dc.subject Working memory en_US
dc.subject Prefrontal cortex en_US
dc.subject Hippocampus en_US
dc.subject Theta rhythm en_US
dc.title Working Memory Performance Correlates with Prefrontal-Hippocampal Theta Interactions but not with Prefrontal Neuron Firing Rates en_US
dc.type article en_US
dc.identifier.doi 10.3389/neuro.07.002.2010 en_US
dc.identifier.pubmedid 20431726 en_US
dc.identifier.pmcid 2861479 en_US

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