A Model for Transient Oxygen Delivery in Cerebral Cortex

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dc.contributor.author Ress, David en_US
dc.contributor.author Thompson, Jeffrey K. en_US
dc.contributor.author Rokers, Bas en_US
dc.contributor.author Khan, Reswanul K. en_US
dc.contributor.author Huk, Alexander C. en_US
dc.date.accessioned 2012-01-09T15:38:51Z
dc.date.available 2012-01-09T15:38:51Z
dc.date.copyright 2009 en_US
dc.date.issued 2009-06-29 en_US
dc.identifier.citation Ress, David, Jeffrey K. Thompson, Bas Rokers, Reswanul K. Khan, Alexander C. Huk. "A Model for Transient Oxygen Delivery in Cerebral Cortex" Frontiers in Neuroenergetics 1 (2009) en_US
dc.identifier.issn 1662-6427 en_US
dc.identifier.uri http://hdl.handle.net/2144/2829
dc.description.abstract Popular hemodynamic brain imaging methods, such as blood oxygen-level dependent functional magnetic resonance imaging (BOLD fMRI), would benefit from a detailed understanding of the mechanisms by which oxygen is delivered to the cortex in response to brief periods of neural activity. Tissue oxygen responses in visual cortex following brief visual stimulation exhibit rich dynamics, including an early decrease in oxygen concentration, a subsequent large increase in concentration, and substantial late-time oscillations ("ringing"). We introduce a model that explains the full time-course of these observations made by Thompson et al. (2003). The model treats oxygen transport with a set of differential equations that include a combination of flow and diffusion in a three-compartment (intravascular, extravascular, and intracellular) system. Blood flow in this system is modeled using the impulse response of a lumped linear system that includes an inertive element; this provides a simple biophysical mechanism for the ringing. The model system is solved numerically to produce excellent fits to measurements of tissue oxygen. The results give insight into the dynamics of cerebral oxygen transfer, and can serve as the starting point to understand BOLD fMRI measurements. en_US
dc.language.iso en en_US
dc.publisher Frontiers Research Foundation en_US
dc.rights Copyright 2009 Ress, Thompson, Rokers, Khan and Huk. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. en_US
dc.rights.uri http://www.frontiersin.org/licenseagreement en_US
dc.subject Oxygen delivery and consumption en_US
dc.subject Brain activation en_US
dc.subject Cerebral hemodynamics en_US
dc.title A Model for Transient Oxygen Delivery in Cerebral Cortex en_US
dc.type article en_US
dc.identifier.doi 10.3389/neuro.14.003.2009 en_US
dc.identifier.pubmedid 19597566 en_US
dc.identifier.pmcid 2709201 en_US

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