Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy

OpenBU

Show simple item record

dc.contributor.author Peter, Angela K. en_US
dc.contributor.author Ko, Christopher Y. en_US
dc.contributor.author Kim, Michelle H. en_US
dc.contributor.author Hsu, Nigel en_US
dc.contributor.author Ouchi, Noriyuki en_US
dc.contributor.author Rhie, Suhn en_US
dc.contributor.author Izumiya, Yasuhiro en_US
dc.contributor.author Zeng, Ling en_US
dc.contributor.author Walsh, Kenneth en_US
dc.contributor.author Crosbie, Rachelle H. en_US
dc.date.accessioned 2012-01-09T15:42:39Z
dc.date.available 2012-01-09T15:42:39Z
dc.date.issued 2008-11-04 en_US
dc.identifier.citation Peter, Angela K., Christopher Y. Ko, Michelle H. Kim, Nigel Hsu, Noriyuki Ouchi, Suhn Rhie, Yasuhiro Izumiya, Ling Zeng, Kenneth Walsh, Rachelle H. Crosbie. "Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy" Human Molecular Genetics 18(2): 318-327. (2008) en_US
dc.identifier.issn 1460-2083 en_US
dc.identifier.uri http://hdl.handle.net/2144/2836
dc.description.abstract Duchenne muscular dystrophy is caused by dystrophin mutations that lead to structural instability of the sarcolemma membrane, myofiber degeneration/regeneration and progressive muscle wasting. Here we show that myogenic Akt signaling in mouse models of dystrophy promotes increased expression of utrophin, which replaces the function of dystrophin thereby preventing sarcolemma damage and muscle wasting. In contrast to previous suggestions that increased Akt in dystrophy was a secondary consequence of pathology, our findings demonstrate a pivotal role for this signaling pathway such that modulation of Akt can significantly affect disease outcome by amplification of existing, physiological compensatory mechanisms. en_US
dc.description.sponsorship National Institutes of Health (T32 GM65823, T32 GM65823); Harold and Lillian Kraus Americal Heart Pre-doctoral Fellowship; Training in Cardiovascular Physiology and Pharmacology Training Grant(5T32HL007444-27); American Heart Association; Muscular Dystrophy Association (MDA3704) en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.title Myogenic Akt Signaling Upregulates the Utrophin-Glycoprotein Complex and Promotes Sarcolemma Stability in Muscular Dystrophy en_US
dc.type article en_US
dc.identifier.doi 10.1093/hmg/ddn358 en_US
dc.identifier.pubmedid 18986978 en_US
dc.identifier.pmcid 2638781 en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search OpenBU


Advanced Search

Browse

Deposit Materials