The Association between Patellar Alignment on Magnetic Resonance Imaging and Radiographic Manifestations of Knee Osteoarthritis


Show simple item record Kalichman, Leonid en_US Zhang, Yuqing en_US Niu, Jingbo en_US Goggins, Joyce en_US Gale, Daniel en_US Zhu, Yanyan en_US Felson, David T en_US Hunter, David J en_US 2012-01-09T20:51:29Z 2012-01-09T20:51:29Z 2007 en_US 2007-3-7 en_US
dc.identifier.citation Kalichman, Leonid, Yuqing Zhang, Jingbo Niu, Joyce Goggins, Daniel Gale, Yanyan Zhu, David T Felson, David J Hunter. "The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis" Arthritis Research & Therapy 9(2):R26. (2007) en_US
dc.identifier.issn 1478-6362 en_US
dc.description.abstract The aim of our study was to evaluate the association between patellar alignment by using magnetic resonance imaging images and radiographic manifestations of patello-femoral osteoarthritis (OA). Subjects were recruited to participate in a natural history study of symptomatic knee OA. We examined the relation of patellar alignment in the sagittal plane (patellar length ratio (PLR)) and the transverse plane (sulcus angle (SA), lateral patellar tilt angle (LPTA), and bisect offset (BO)) to radiographic features of patello-femoral OA, namely joint space narrowing and patellar osteophytes, using a proportional odds logistic regression model while adjusting for age, sex, and bone mass index (BMI). The study sample consisted of 126 males (average age 68.0 years, BMI 31.2) and 87 females (average age 64.7 years, BMI 31.6), 75% of whom had tibiofemoral OA (a Kellgren-Lawrence score of 2 or more). PLR showed a statistically significant association with joint space narrowing and osteophytosis in the lateral compartment. SA showed significant association with medial joint space narrowing and with lateral and medial patellar osteophytosis. LPTA and BO showed significant association with both radiographic indices of the lateral compartment. Clear linear trends were found in association between PLR, LPTA and BO, and with outcomes associated with lateral patello-femoral OA. SA, LPTA, and BO showed linear trends of association with medial joint space narrowing. Results of our study clearly suggest the association between indices of patellar alignment and such features of patello-femoral OA as osteophytosis and joint space narrowing. Additional studies will be required to establish the normal and abnormal ranges of patellar alignment indices and their longitudinal relation to patello-femoral OA. en_US
dc.description.sponsorship National Institutes of Health (AR47785); Arthritis Foundation (Osteoarthritis Biomarkers Grant); Arthritis Foundation Clinical Sciences Grant en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2007 Kalichman et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title The Association between Patellar Alignment on Magnetic Resonance Imaging and Radiographic Manifestations of Knee Osteoarthritis en_US
dc.type article en_US
dc.identifier.doi 10.1186/ar2138 en_US
dc.identifier.pubmedid 17343731 en_US
dc.identifier.pmcid 1906802 en_US

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