Impact of Non-Ignorable Missingness on Genetic Tests of Linkage and/or Association Using Case-Parent Trios


Show simple item record Guo, Chao-Yu en_US Cui, Jing en_US Cupples, L Adrienne en_US 2012-01-09T20:53:14Z 2012-01-09T20:53:14Z 2005 en_US 2005-12-30 en_US
dc.identifier.citation Guo, Chao-Yu, Jing Cui, L Adrienne Cupples. "Impact of non-ignorable missingness on genetic tests of linkage and/or association using case-parent trios" BMC Genetics 6(Suppl 1):S90. (2005) en_US
dc.identifier.issn 1471-2156 en_US
dc.description.abstract The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. When parental information is non-randomly missing, due, for example, to death from the disease under study, the impact on type I error and power under dominant and recessive disease models has been reported. In this paper, we examine non-ignorable missingness by assigning missing values to the genotypes of affected parents. We used unrelated case-parent trios in the Genetic Analysis Workshop 14 simulated data for the Danacaa population. Our computer simulations revealed that the type I error of these tests using incomplete trios was not inflated over the nominal level under either recessive or dominant disease models. However, the power of these tests appears to be inflated over the complete information case due to an excess of heterozygous parents in dyads. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2005 Guo et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title Impact of Non-Ignorable Missingness on Genetic Tests of Linkage and/or Association Using Case-Parent Trios en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2156-6-S1-S90 en_US
dc.identifier.pubmedid 16451706 en_US
dc.identifier.pmcid 1866689 en_US

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