The Urban Environment and Childhood Asthma (URECA) Birth Cohort Study: Design, Methods, and Study Population


Show simple item record Gern, James E en_US Visness, Cynthia M en_US Gergen, Peter J en_US Wood, Robert A en_US Bloomberg, Gordon R en_US O'Connor, George T en_US Kattan, Meyer en_US Sampson, Hugh A en_US Witter, Frank R en_US Sandel, Megan T en_US Shreffler, Wayne G en_US Wright, Rosalind J en_US Arbes, Samuel J en_US Busse, William W en_US 2012-01-09T20:54:50Z 2012-01-09T20:54:50Z 2009 en_US 2009-5-8 en_US
dc.identifier.citation Gern, James E, Cynthia M Visness, Peter J Gergen, Robert A Wood, Gordon R Bloomberg, George T O'Connor, Meyer Kattan, Hugh A Sampson, Frank R Witter, Megan T Sandel, Wayne G Shreffler, Rosalind J Wright, Samuel J Arbes, William W Busse. "The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population" BMC Pulmonary Medicine 9:17. (2009) en_US
dc.identifier.issn 1471-2466 en_US
dc.description.abstract BACKGROUND. The incidence and morbidity of wheezing illnesses and childhood asthma is especially high in poor urban areas. This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA) study, which was established to investigate the immunologic causes of asthma among inner-city children. METHODS AND RESULTS. URECA is an observational prospective study that enrolled pregnant women in central urban areas of Baltimore, Boston, New York City, and St. Louis and is following their offspring from birth through age 7 years. The birth cohort consists of 560 inner-city children who have at least one parent with an allergic disease or asthma, and all families live in areas in which at least 20% of the population has incomes below the poverty line. In addition, 49 inner-city children with no parental history of allergies or asthma were enrolled. The primary hypothesis is that specific urban exposures in early life promote a unique pattern of immune development (impaired antiviral and increased Th2 responses) that increases the risk of recurrent wheezing and allergic sensitization in early childhood, and of asthma by age 7 years. To track immune development, cytokine responses of blood mononuclear cells stimulated ex vivo are measured at birth and then annually. Environmental assessments include allergen and endotoxin levels in house dust, pre- and postnatal maternal stress, and indoor air nicotine and nitrogen dioxide. Nasal mucous samples are collected from the children during respiratory illnesses and analyzed for respiratory viruses. The complex interactions between environmental exposures and immune development will be assessed with respect to recurrent wheeze at age 3 years and asthma at age 7 years. CONCLUSION. The overall goal of the URECA study is to develop a better understanding of how specific urban exposures affect immune development to promote wheezing illnesses and asthma. en_US
dc.description.sponsorship National Institutes of Health National Institute of Allergy and Infectious Diseases (NO1-A11-25496, NO1-A1-25482); National Institutes of Health National Center for Research Resources (RR00052, M01RR00533, M01RR00071, SULIRR024992-02) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2009 Gern et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title The Urban Environment and Childhood Asthma (URECA) Birth Cohort Study: Design, Methods, and Study Population en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2466-9-17 en_US
dc.identifier.pubmedid 19426496 en_US
dc.identifier.pmcid 2689166 en_US

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