Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity

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dc.contributor.author Mogues, Tirsit en_US
dc.contributor.author Etzerodt, Michael en_US
dc.contributor.author Hall, Crystal en_US
dc.contributor.author Engelich, Georg en_US
dc.contributor.author Graversen, Jonas H. en_US
dc.contributor.author Hartshorn, Kevan L. en_US
dc.date.accessioned 2012-01-09T20:56:59Z
dc.date.available 2012-01-09T20:56:59Z
dc.date.issued 2004 en_US
dc.identifier.citation Mogues, Tirsit, Michael Etzerodt, Crystal Hall, Georg Engelich, Jonas H. Graversen, Kevan L. Hartshorn. "Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity" Journal of Biomedicine and Biotechnology 2004(2): 73-78. en_US
dc.identifier.issn 1110-7251 en_US
dc.identifier.uri http://hdl.handle.net/2144/2921
dc.description.abstract Tetranectin is a plasminogen kringle 4 domain-binding protein present in plasma and various tissue locations. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and adverse prognosis. A possible mechanism through which tetranectin could influence cancer progression is by altering activities of plasminogen or the plasminogen fragment, angiostatin. Tetranectin was found to bind to the kringle 1-4 form of angiostatin (ASTK1-4). In addition, tetranectin inhibited binding of plasminogen or ASTK1-4 to extracellular matrix (ECM) deposited by endothelial cells. Finally, tetranectin partially counteracted the ability of ASTK1-4 to inhibit proliferation of endothelial cells. This latter effect of tetranectin was specific for ASTK1-4 since it did not counteract the antiproliferative activities of the kringle 1-3 form of angiostatin (ASTK1-3) or endostatin. These findings suggest that tetranectin may modulate angiogenesis through interactions with AST. en_US
dc.description.sponsorship National Institutes of Health (HL69031) en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights en_US
dc.title Tetranectin Binds to the Kringle 1-4 Form of Angiostatin and Modifies Its Functional Activity en_US
dc.type article en_US
dc.identifier.doi 10.1155/S1110724304307096 en_US
dc.identifier.pubmedid 15240916 en_US
dc.identifier.pmcid 548802 en_US

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