Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine Is Effective in Preventing Maternal and Placental Malaria in Ibadan, South-Western Nigeria

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dc.contributor.author Falade, Catherine O en_US
dc.contributor.author Yusuf, Bidemi O en_US
dc.contributor.author Fadero, Francis F en_US
dc.contributor.author Mokuolu, Olugbenga A en_US
dc.contributor.author Hamer, Davidson H en_US
dc.contributor.author Salako, Lateef A en_US
dc.date.accessioned 2012-01-09T20:58:39Z
dc.date.available 2012-01-09T20:58:39Z
dc.date.copyright 2007 en_US
dc.date.issued 2007-7-6 en_US
dc.identifier.citation Falade, Catherine O, Bidemi O Yusuf, Francis F Fadero, Olugbenga A Mokuolu, Davidson H Hamer, Lateef A Salako. "Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria" Malaria Journal 6:88. (2007) en_US
dc.identifier.issn 1475-2875 en_US
dc.identifier.uri http://hdl.handle.net/2144/2946
dc.description.abstract BACKGROUND Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Ibadan, Nigeria, where the risk of malaria is present all year round. METHOD During a larger study evaluating the epidemiology of congenital malaria, the effect of malaria prophylaxis was examined in 983 parturient mothers. Five hundred and ninety eight mothers (60.8%) received IPT-SP, 214 (21.8%) received pyrimethamine (PYR) and 171 (17.4%) did not take any chemoprophylactic agent (NC). RESULTS The prevalence of maternal parasitaemia in the IPT-SP, PYR and NC groups was 10.4%, 15.9% and 17% respectively (p = 0.021). The prevalence of placental parasitaemia was 10.5% in the IPT-SP, 16.8% PYR and 17% NC groups, respectively (p = 0.015). The prevalence of maternal anaemia (haematocrit <30%) was 5.7% vs. 8.9% vs. 13.4% among the IPT-SP, PYR and NC groups respectively (p <0.0001) while that of pre-term delivery (GA <37 weeks) was 10.5%, 19.2% and 25.3% among IPT-SP, PYR and NC groups respectively (p <0.0001). Babies born to mothers in the IPT-SP, PYR and NC groups had mean birth weights of 3204 ± 487.16, 3075 ± 513.24 and 3074 ± 505.92 respectively (ρ <0.0001). There was a trend towards a lower proportion of low birth weight babies in the IPT-SP group (p = 0.095). CONCLUSION IPT-SP is effective in preventing maternal and placental malaria as well as improving pregnancy outcomes among parturient women in Ibadan, Nigeria. The implementation of the recently adopted IPT-SP strategy should be pursued with vigour as it holds great promise for reducing the burden of malaria in pregnancy in Nigeria. en_US
dc.description.sponsorship Cooperative Agreement between Boston University and the Office of Health and Nutrition of the United States Agency for International Development en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2007 Falade et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Intermittent Preventive Treatment with Sulphadoxine-Pyrimethamine Is Effective in Preventing Maternal and Placental Malaria in Ibadan, South-Western Nigeria en_US
dc.type article en_US
dc.identifier.doi 10.1186/1475-2875-6-88 en_US
dc.identifier.pubmedid 17617910 en_US
dc.identifier.pmcid 1941736 en_US

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