Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection

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dc.contributor.author Geisbert, Thomas W. en_US
dc.contributor.author Daddario-DiCaprio, Kathleen M. en_US
dc.contributor.author Hickey, Andrew C. en_US
dc.contributor.author Smith, Mark A. en_US
dc.contributor.author Chan, Yee-Peng en_US
dc.contributor.author Wang, Lin-Fa en_US
dc.contributor.author Mattapallil, Joseph J. en_US
dc.contributor.author Geisbert, Joan B. en_US
dc.contributor.author Bossart, Katharine N. en_US
dc.contributor.author Broder, Christopher C. en_US
dc.date.accessioned 2012-01-09T21:00:24Z
dc.date.available 2012-01-09T21:00:24Z
dc.date.issued 2010-5-18 en_US
dc.identifier.citation Geisbert, Thomas W., Kathleen M. Daddario-DiCaprio, Andrew C. Hickey, Mark A. Smith, Yee-Peng Chan, Lin-Fa Wang, Joseph J. Mattapallil, Joan B. Geisbert, Katharine N. Bossart, Christopher C. Broder. "Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection" PLoS ONE 5(5): e10690. (2010) en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/2144/2978
dc.description.abstract Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent and there are no vaccines or treatments approved for human use. Guinea pigs, hamsters, cats, ferrets, pigs and most recently squirrel monkeys (New World monkey) have been evaluated as animal models of human NiV infection, and with the exception of the ferret, no model recapitulates all aspects of NiV-mediated disease seen in humans. To identify a more viable nonhuman primate (NHP) model, we examined the pathogenesis of NiV in African green monkeys (AGM). Exposure of eight monkeys to NiV produced a severe systemic infection in all eight animals with seven of the animals succumbing to infection. Viral RNA was detected in the plasma of challenged animals and occurred in two of three subjects as a peak between days 7 and 21, providing the first clear demonstration of plasma-associated viremia in NiV experimentally infected animals and suggested a progressive infection that seeded multiple organs simultaneously from the initial site of virus replication. Unlike the cat, hamster and squirrel monkey models of NiV infection, severe respiratory pathology, neurological disease and generalized vasculitis all manifested in NiV-infected AGMs, providing an accurate reflection of what is observed in NiV-infected humans. Our findings demonstrate the first consistent and highly pathogenic NHP model of NiV infection, providing a new and critical platform in the evaluation and licensure of either passive and active immunization or therapeutic strategies for human use. en_US
dc.description.sponsorship Department of Health and Human Services; National Institutes of Health (AI082121, AI057159, DE018339, DE019397, AI071812, AI05471, AI077995) en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. en_US
dc.title Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0010690 en_US
dc.identifier.pubmedid 20502528 en_US
dc.identifier.pmcid 2872660 en_US

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