Comparisons of Case-Selection Approaches Based on Allele Sharing and/or Disease Severity Index: Application to the GAW14 Simulated Data

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dc.contributor.author Liu, Chunyu en_US
dc.contributor.author Cupples, L Adrienne en_US
dc.contributor.author Dupuis, Josée en_US
dc.date.accessioned 2012-01-11T15:51:12Z
dc.date.available 2012-01-11T15:51:12Z
dc.date.copyright 2005 en_US
dc.date.issued 2005-12-30 en_US
dc.identifier.citation Liu, Chunyu, L Adrienne Cupples, Josée Dupuis. "Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data" BMC Genetics 6(Suppl 1):S103. (2005) en_US
dc.identifier.issn 1471-2156 en_US
dc.identifier.uri http://hdl.handle.net/2144/3076
dc.description.abstract For mapping complex disease traits, linkage studies are often followed by a case-control association strategy in order to identify disease-associated genes/single-nucleotide polymorphisms (SNPs). Substantial efforts are required in selecting the most informative cases from a large collection of affected individuals in order to maximize the power of the study, while taking into consideration study cost. In this article, we applied and extended three case-selection strategies that use allele-sharing information method for families with multiple affected offspring to select most informative cases using additional information on disease severity. Our results revealed that most significant associations, as measured by the lowest p-values, were obtained from a strategy that selected a case with the most allele sharing with other affected sibs from linked families ("linked-best"), despite reduction in sample size resulting from discarding unlinked families. Moreover, information on disease severity appears to be useful to improve the ability to detect associations between markers and disease loci. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2005 Liu et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Comparisons of Case-Selection Approaches Based on Allele Sharing and/or Disease Severity Index: Application to the GAW14 Simulated Data en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-2156-6-S1-S103 en_US
dc.identifier.pubmedid 16451559 en_US
dc.identifier.pmcid 1866836 en_US

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