The impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT)

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dc.contributor.author Guo, Chao-Yu en_US
dc.date.accessioned 2012-01-11T17:18:24Z
dc.date.available 2012-01-11T17:18:24Z
dc.date.copyright 2007 en_US
dc.date.issued 2007-12-18 en_US
dc.identifier.citation Guo, Chao-Yu. "The impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT)" BMC Proceedings 1(Suppl 1):S26. (2007) en_US
dc.identifier.issn 1753-6561 en_US
dc.identifier.uri http://hdl.handle.net/2144/3145
dc.description.abstract The transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete triads. Some strategies assumed that parental genotypes were missing completely at random and some methods allowed informative missingness for parental genotypes. However, the above tests assumed that offspring genotypes were missing completely at random and concluded that the transmission/disequilibrium test remained a valid test by excluding incomplete triads from the analysis. In this article, the conditional distribution of ascertained triads allowing informative missingness for offspring genotypes, as well as their parental genotypes, was derived and several tests under such scenarios were evaluated. In simulations, independent triads from the Genetic Analysis Workshop 15 simulated data (Problem 3) was ascertained. When offspring genotypes were missing informatively, simulation results revealed inflated type I error and/or reduced power for the transmission/disequilibrium test excluding incomplete triads. en_US
dc.description.sponsorship National Heart, Lung and Blood Institute's Framingham Heart Study (N01-HC-25195) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2007 Guo; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title The impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT) en_US
dc.type article en_US
dc.identifier.pubmedid 18466523 en_US
dc.identifier.pmcid 2367473 en_US

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