Migraine and Risk of Haemorrhagic Stroke in Women: Prospective Cohort Study

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dc.contributor.author Kurth, Tobias en_US
dc.contributor.author Kase, Carlos S en_US
dc.contributor.author Schürks, Markus en_US
dc.contributor.author Tzourio, Christophe en_US
dc.contributor.author Buring, Julie E en_US
dc.date.accessioned 2012-01-11T21:07:26Z
dc.date.available 2012-01-11T21:07:26Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-8-24 en_US
dc.identifier.citation Kurth, Tobias, Carlos S Kase, Markus Schürks, Christophe Tzourio, Julie E Buring. "Migraine and risk of haemorrhagic stroke in women: prospective cohort study" BMJ: British Medical Journal 341:c3659. (2010) en_US
dc.identifier.issn 1468-5833 en_US
dc.identifier.uri http://hdl.handle.net/2144/3171
dc.description.abstract Objectives To examine the association between migraine and migraine aura status with risk of haemorrhagic stroke. Design Prospective cohort study. Setting Women's Health Study, United States. Participants 27860 women aged ≥45 who were free from stroke or other major disease at baseline and had provided information on self reported migraine, aura status, and lipid values. Main outcome measures Time to first haemorrhagic stroke and subtypes of haemorrhagic stroke. Results At baseline, 5130 (18%) women reported any history of migraine; of the 3612 with active migraine (migraine in the previous year), 1435 (40%) described having aura. During a mean of 13.6 years of follow-up, 85 haemorrhagic strokes were confirmed after review of medical records. Compared with women without a history of migraine, there was no increased risk of haemorrhagic stroke in those who reported any history of migraine (adjusted hazard ratio 0.98, 95% confidence interval 0.56 to 1.71, P=0.93). In contrast, risk was increased in women with active migraine with aura (2.25, 1.11 to 4.54, P=0.024). The age adjusted increased risk was stronger for intracerebral haemorrhage (2.78, 1.09 to 7.07, P=0.032) and for fatal events (3.56, 1.23 to 10.31, P=0.02). Four additional haemorrhagic stroke events were attributable to migraine with aura per 10000 women per year. Women who reported active migraine without aura had no increased risk for haemorrhagic stroke. Conclusion Migraine with aura might, in addition to ischaemic events, also be a risk factor for haemorrhagic stroke. The relatively low number of events and attributable risk should caution against definitive conclusions and call for further confirmation of these observations. en_US
dc.description.sponsorship National Heart, Lung and Blood Institute (HL-043851, HL-080467); National Cancer Institute (CA-47988); Donald W Reynolds Foundation; Leducq Foundation; Doris Duke Charitable Foundation en_US
dc.language.iso en en_US
dc.publisher BMJ Publishing Group Ltd. en_US
dc.rights Copyright Kurth et al 2010 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. en_US
dc.title Migraine and Risk of Haemorrhagic Stroke in Women: Prospective Cohort Study en_US
dc.type article en_US
dc.identifier.doi 10.1136/bmj.c3659 en_US
dc.identifier.pubmedid 20736268 en_US
dc.identifier.pmcid 2927695 en_US

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