Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study

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dc.contributor.author Wu, Yuntao en_US
dc.contributor.author Yoder, Alyson en_US
dc.contributor.author Yu, Dongyang en_US
dc.contributor.author Wang, Weifeng en_US
dc.contributor.author Liu, Juan en_US
dc.contributor.author Barrett, Tracey en_US
dc.contributor.author Wheeler, David en_US
dc.contributor.author Schlauch, Karen en_US
dc.date.accessioned 2012-01-11T22:28:24Z
dc.date.available 2012-01-11T22:28:24Z
dc.date.copyright 2008 en_US
dc.date.issued 2008-10-17 en_US
dc.identifier.citation Wu, Yuntao, Alyson Yoder, Dongyang Yu, Weifeng Wang, Juan Liu, Tracey Barrett, David Wheeler, Karen Schlauch. "Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study" Retrovirology 5:95. (2008) en_US
dc.identifier.issn 1742-4690 en_US
dc.identifier.uri http://hdl.handle.net/2144/3302
dc.description.abstract Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis. en_US
dc.description.sponsorship Department of Defense (National Defense Science and Engineering Fellowship); National Institute of Allergy and Infectious Diseases (AI069981) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2008 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1742-4690-5-95 en_US
dc.identifier.pubmedid 18928553 en_US
dc.identifier.pmcid 2576353 en_US

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