Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study


Show simple item record Wu, Yuntao en_US Yoder, Alyson en_US Yu, Dongyang en_US Wang, Weifeng en_US Liu, Juan en_US Barrett, Tracey en_US Wheeler, David en_US Schlauch, Karen en_US 2012-01-11T22:28:24Z 2012-01-11T22:28:24Z 2008 en_US 2008-10-17 en_US
dc.identifier.citation Wu, Yuntao, Alyson Yoder, Dongyang Yu, Weifeng Wang, Juan Liu, Tracey Barrett, David Wheeler, Karen Schlauch. "Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study" Retrovirology 5:95. (2008) en_US
dc.identifier.issn 1742-4690 en_US
dc.description.abstract Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis. en_US
dc.description.sponsorship Department of Defense (National Defense Science and Engineering Fellowship); National Institute of Allergy and Infectious Diseases (AI069981) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2008 Wu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study en_US
dc.type article en_US
dc.identifier.doi 10.1186/1742-4690-5-95 en_US
dc.identifier.pubmedid 18928553 en_US
dc.identifier.pmcid 2576353 en_US

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