Spectral and Spatial Dependence of Diffuse Optical Signals in Response to Peripheral Nerve Stimulation

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dc.contributor.author Chen, Debbie K. en_US
dc.contributor.author Erb, M. Kelley en_US
dc.contributor.author Tong, Yunjie en_US
dc.contributor.author Yu, Yang en_US
dc.contributor.author Sassaroli, Angelo en_US
dc.contributor.author Bergethon, Peter R. en_US
dc.contributor.author Fantini, Sergio en_US
dc.date.accessioned 2012-01-11T23:13:27Z
dc.date.available 2012-01-11T23:13:27Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-9-16 en_US
dc.identifier.citation Chen, Debbie K., M. Kelley Erb, Yunjie Tong, Yang Yu, Angelo Sassaroli, Peter R. Bergethon, Sergio Fantini. "Spectral and spatial dependence of diffuse optical signals in response to peripheral nerve stimulation" Biomedical Optics Express 1(3): 923-942. (2010) en_US
dc.identifier.issn 2156-7085 en_US
dc.identifier.uri http://hdl.handle.net/2144/3320
dc.description.abstract Using non-invasive, near-infrared spectroscopy we have previously reported optical signals measured at or around peripheral nerves in response to their stimulation. Such optical signals featured amplitudes on the order of 0.1% and peaked about 100 ms after peripheral nerve stimulation in human subjects. Here, we report a study of the spatial and spectral dependence of the optical signals induced by stimulation of the human median and sural nerves, and observe that these optical signals are: (1) unlikely due to either dilation or constriction of blood vessels, (2) not associated with capillary bed hemoglobin, (3) likely due to blood vessel(s) displacement, and (4) unlikely due to fiber-skin optical coupling effects. We conclude that the most probable origin of the optical response to peripheral nerve stimulation is from displacement of blood vessels within the optically probed volume, as a result of muscle twitch in adjacent areas. en_US
dc.description.sponsorship National Institutes of Health (R01-NS059933); U.S. Army Medical Acquisition Activity (W81XWH-07-2-0011) en_US
dc.language.iso en en_US
dc.publisher Optical Society of America en_US
dc.rights Copyright 2010 Optical Society of America This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/ en_US
dc.subject (170.0170) Medical optics and biotechnology en_US
dc.subject (170.2655) Functional monitoring and imaging en_US
dc.subject (170.3660) Light propagation in tissues en_US
dc.title Spectral and Spatial Dependence of Diffuse Optical Signals in Response to Peripheral Nerve Stimulation en_US
dc.type article en_US
dc.identifier.doi 10.1364/BOE.1.000923 en_US
dc.identifier.pmcid 3018062 en_US

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