Cognitive Aging in Zebrafish

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dc.contributor.author Yu, Lili en_US
dc.contributor.author Tucci, Valter en_US
dc.contributor.author Kishi, Shuji en_US
dc.contributor.author Zhdanova, Irina V. en_US
dc.date.accessioned 2012-01-11T23:13:28Z
dc.date.available 2012-01-11T23:13:28Z
dc.date.issued 2006-12-20 en_US
dc.identifier.citation Yu, Lili, Valter Tucci, Shuji Kishi, Irina V. Zhdanova. "Cognitive Aging in Zebrafish" PLoS ONE 1(1):e14. (2006) en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/2144/3324
dc.description.abstract BACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and environmental factors that determine the deterioration or preservation of cognitive abilities throughout life. METHODOLOGY/PRINCIPAL FINDINGS. Behavior of wild-type, mutant and gamma-irradiated zebrafish (Danio rerio) was documented using image-analysis technique. Conditioned responses to spatial, visual and temporal cues were investigated in young, middle-aged and old animals. The results demonstrate that zebrafish aging is associated with changes in cognitive responses to emotionally positive and negative experiences, reduced generalization of adaptive associations, increased stereotypic and reduced exploratory behavior and altered temporal entrainment. Genetic upregulation of cholinergic transmission attenuates cognitive decline in middle-aged achesb55/+ mutants, compared to wild-type siblings. In contrast, the genotoxic stress of gamma-irradiation accelerates the onset of cognitive impairment in young zebrafish. CONCLUSIONS/SIGNIFICANCE. These findings would allow the use of powerful molecular biological resources accumulated in the zebrafish field to address the mechanisms of cognitive senescence, and promote the search for therapeutic strategies which may attenuate age-related cognitive decline. en_US
dc.description.sponsorship National Institutes of Health (MH065528, AG02264); Chaikin-Wile foundation; Ellison Medical Foundation en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.title Cognitive Aging in Zebrafish en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0000014 en_US
dc.identifier.pubmedid 17183640 en_US
dc.identifier.pmcid 1762370 en_US

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