The Role of Disorder in Interaction Networks: A Structural Analysis


Show simple item record Kim, Philip M en_US Sboner, Andrea en_US Xia, Yu en_US Gerstein, Mark en_US 2012-01-12T16:40:40Z 2012-01-12T16:40:40Z 2008-03-25 en_US
dc.identifier.citation Kim, Philip M, Andrea Sboner, Yu Xia, Mark Gerstein. "The role of disorder in interaction networks: a structural analysis" Molecular Systems Biology 4:179. (2008) en_US
dc.identifier.issn 1744-4292 en_US
dc.description.abstract Recent studies have emphasized the value of including structural information into the topological analysis of protein networks. Here, we utilized structural information to investigate the role of intrinsic disorder in these networks. Hub proteins tend to be more disordered than other proteins (i.e. the proteome average); however, we find this only true for those with one or two binding interfaces ('single'-interface hubs). In contrast, the distribution of disordered residues in multi-interface hubs is indistinguishable from the overall proteome. Surprisingly, we find that the binding interfaces in single-interface hubs are highly structured, as is the case for multi-interface hubs. However, the binding partners of single-interface hubs tend to have a higher level of disorder than the proteome average, suggesting that their binding promiscuity is related to the disorder of their binding partners. In turn, the higher level of disorder of single-interface hubs can be partly explained by their tendency to bind to each other in a cascade. A good illustration of this trend can be found in signaling pathways and, more specifically, in kinase cascades. Finally, our findings have implications for the current controversy related to party and date-hubs. en_US
dc.description.sponsorship National Institutes of Health (RR19895) en_US
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.rights This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. en_US
dc.rights.uri en_US
dc.subject Hubs en_US
dc.subject Intrinsic disorder en_US
dc.subject Structural networks en_US
dc.title The Role of Disorder in Interaction Networks: A Structural Analysis en_US
dc.type article en_US
dc.identifier.doi 10.1038/msb.2008.16 en_US
dc.identifier.pubmedid 18364713 en_US
dc.identifier.pmcid 2290937 en_US

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