Nonlinear Modeling of Venous Leg Ulcer Healing Rates


Show simple item record Cardinal, Matthew en_US Phillips, Tania en_US Eisenbud, David E en_US Harding, Keith en_US Mansbridge, Jonathan en_US Armstrong, David G en_US 2012-01-12T17:35:45Z 2012-01-12T17:35:45Z 2009 en_US 2009-3-31 en_US
dc.identifier.citation Cardinal, Matthew, Tania Phillips, David E Eisenbud, Keith Harding, Jonathan Mansbridge, David G Armstrong. "Nonlinear modeling of venous leg ulcer healing rates" BMC Dermatology 9:2. (2009) en_US
dc.identifier.issn 1471-5945 en_US
dc.description.abstract BACKGROUND. The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics. METHODS. We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments. RESULTS. A majority (72%) of VLUs exhibited surface area reduction via an exponential decay model, particularly during the early stages of healing. These results were consistent with the mechanics of wound contraction and epithelial cell proliferation, supported by the higher frequency at which exponential surface area reduction associated with full wound closure (35% of wounds that fit the exponential model healed vs. 21% of wounds that did not fit the exponential model completely healed during the study period, p = 0.018). Goodness-of-fit statistics suggested that much of the individual variation in healing could be described as nonlinear variation from the exponential model. CONCLUSION. We believe that parameter estimates from a mathematical model may provide a more accurate quantification of wound healing rates, and that similar models may someday reach routine use in comparing the efficacy of various treatments in routine practice and in product registration trials. en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2009 Cardinal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri en_US
dc.title Nonlinear Modeling of Venous Leg Ulcer Healing Rates en_US
dc.type article en_US
dc.identifier.doi 10.1186/1471-5945-9-2 en_US
dc.identifier.pubmedid 19335882 en_US
dc.identifier.pmcid 2672927 en_US

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