Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes

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dc.contributor.author Park, Hee-Young en_US
dc.contributor.author Wu, Christina en_US
dc.contributor.author Yaar, Mina en_US
dc.contributor.author Stachur, Christina M. en_US
dc.contributor.author Kosmadaki, Marita en_US
dc.contributor.author Gilchrest, Barbara A. en_US
dc.date.accessioned 2012-01-12T17:35:45Z
dc.date.available 2012-01-12T17:35:45Z
dc.date.copyright 2009 en_US
dc.date.issued 2009-12-30 en_US
dc.identifier.citation Park, Hee-Young, Christina Wu, Mina Yaar, Christina M. Stachur, Marita Kosmadaki, Barbara A. Gilchrest. "Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes" International Journal of Cell Biology 2009:750482. en_US
dc.identifier.issn 1687-8884 en_US
dc.identifier.uri http://hdl.handle.net/2144/3403
dc.description.abstract Bone Morphogenetic Protein (BMP-4) was shown to down-regulate melanogenesis, in part, by decreasing the level of tyrosinase [Yaar et al. (2006) JBC:281]. Results presented here show that BMP-4 down-regulated the protein levels of TRP-1, PKC-β, and MCI-R. When paired cultures of human melanocytes were treated with vehicle or BMP-4 (25ng/ml), MAPK/ERK were phosphorylated within one hour of BMP-4 treatment. Then the activated MAPK/ERK caused an acute phosphorylation of MITF, followed by proteosome-mediated degradation of MITF, the key transcription factor for melanogenic proteins [Wu et al. (2000) Gene & Development:14]. However, prolonged exposure of melanocytes to BMP-4 (up to 48 hours) caused a decrease in the level of MITF-M transcript. In addition, BMP-4 decreased the intracellular level of cAMP, the key regulator of MITF expression. These results demonstrate that BMP-4 activates MAPK/ERK signaling pathway to transiently activate MITF; however, chronic treatment of BMP-4 to melanocytes causes a down-regulation of the expression of MITF, possibly in a cAMP-dependent pathway. en_US
dc.description.sponsorship Amal K. Kurban Career Development Award and National Vitiligo Foundation en_US
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights Copyright 2009 Hee-Young Park et al. en_US
dc.title Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes en_US
dc.type article en_US
dc.identifier.doi 10.1155/2009/750482 en_US
dc.identifier.pubmedid 20130821 en_US
dc.identifier.pmcid 2814237 en_US

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