Longitudinal Assessment of Cyst-Like Lesions of the Knee and Their Relation to Radiographic Osteoarthritis and MRI-Detected Effusion and Synovitis in Patients with Knee Pain


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dc.contributor.author Hayashi, Daichi en_US
dc.contributor.author Roemer, Frank W en_US
dc.contributor.author Dhina, Zineb en_US
dc.contributor.author Kwoh, C Kent en_US
dc.contributor.author Hannon, Michael J en_US
dc.contributor.author Moore, Carolyn en_US
dc.contributor.author Guermazi, Ali en_US
dc.date.accessioned 2012-01-12T17:38:57Z
dc.date.available 2012-01-12T17:38:57Z
dc.date.copyright 2010 en_US
dc.date.issued 2010-9-15 en_US
dc.identifier.citation Hayashi, Daichi, Frank W Roemer, Zineb Dhina, C Kent Kwoh, Michael J Hannon, Carolyn Moore, Ali Guermazi. "Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain" Arthritis Research & Therapy 12(5):R172. (2010) en_US
dc.identifier.issn 1478-6362 en_US
dc.identifier.uri http://hdl.handle.net/2144/3414
dc.description.abstract INTRODUCTION. The purpose of the present study was to determine the prevalence of cystic lesions and cyst-like bursitides in subjects with frequent knee pain and to assess their relation to radiographic osteoarthritis (OA) severity; to describe bilaterality and size fluctuation of the lesions over 6 months; and to assess relations between the prevalence of synovium-lined lesions communicating with the joint capsule and severity of magnetic resonance imaging (MRI)-detected effusion and synovitis. METHODS. One hundred and sixty-three subjects (total 319 knees) aged 35 to 65 with chronic, frequent knee pain were included. Imaging with 3 Tesla MRI was performed at baseline and 6-month follow-up with the same protocols as those used in the Osteoarthritis Initiative. Severity of radiographic OA was assessed using the Kellgren-Lawrence grade (0 to 4). Severity of effusion and synovitis was graded 0 to 3 based on the Whole Organ Magnetic Resonance Imaging Score system. The associations of cysts and cyst-like bursitides and severity of radiographic OA, MRI-detected effusion and synovitis were analyzed using logistic regression controlling for clustering by person. The Wilcoxon signed-rank test was used to determine whether there was a significant change in the size of lesions between baseline and follow-up. RESULTS. At least one lesion (any type) was present in 222 (70%) knees. The most prevalent lesions were popliteal cysts (40%, 128/319), followed by subgastrocnemius bursitis (15%, 49/319) and proximal tibiofibular joint cysts (8%, 26/319). Bilateral lesions were seen in 49% of the subjects. Only popliteal cysts and subgastrocnemius bursitis showed a significant change in size (P < 0.001). No trend was observed between prevalence of any of the cyst-like lesions analyzed and the increasing radiographic OA severity. Increasing prevalence of subgastrocnemius bursitis was associated with increasing severity of effusion (P = 0.0072) and synovitis (P = 0.0033). CONCLUSIONS. None of the cyst-like lesions analyzed seems to be a marker of radiographic OA severity in knees with chronic frequent pain. Subgastrocnemius bursitis may be used as a marker of effusion/synovitis severity. Bilateral cyst-like lesions are relatively commonly observed in people with chronic knee pain. en_US
dc.description.sponsorship The Beverage Institute en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2010 Hayashi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title Longitudinal Assessment of Cyst-Like Lesions of the Knee and Their Relation to Radiographic Osteoarthritis and MRI-Detected Effusion and Synovitis in Patients with Knee Pain en_US
dc.type article en_US
dc.identifier.doi 10.1186/ar3132 en_US
dc.identifier.pubmedid 20843319 en_US
dc.identifier.pmcid 2990999 en_US

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