Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population

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dc.contributor.author Bare, Lance A. en_US
dc.contributor.author Ruiz-Narvaéz, Edward A. en_US
dc.contributor.author Tong, Carmen H. en_US
dc.contributor.author Arellano, Andre R. en_US
dc.contributor.author Rowland, Charles M. en_US
dc.contributor.author Catanese, Joseph J. en_US
dc.contributor.author Sacks, Frank M. en_US
dc.contributor.author Devlin, James J. en_US
dc.contributor.author Campos, Hannia en_US
dc.date.accessioned 2012-01-12T17:43:32Z
dc.date.available 2012-01-12T17:43:32Z
dc.date.issued 2010-9-29 en_US
dc.identifier.citation Bare, Lance A., Edward A. Ruiz-Narvaéz, Carmen H. Tong, Andre R. Arellano, Charles M. Rowland, Joseph J. Catanese, Frank M. Sacks, James J. Devlin, Hannia Campos. "Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population" PLoS ONE 5(9): e13081. (2010) en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/2144/3429
dc.description.abstract BACKGROUND AND METHODOLOGY. The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with non-fatal myocardial infarction (MI) in a case-control study of an admixed population from the Central Valley of Costa Rica. Genotypes of the KIF6 variant were determined for 4,134 men and women. Cases (1,987) had survived a first MI; controls (2,147) had no history of MI and were matched to cases by age, sex, and area of residence. We tested the association between the KIF6 719Arg allele and non-fatal MI by conditional logistic regression and adjusted for admixture of founder populations. PRINCIPAL FINDINGS. Compared with the reference Trp/Trp homozygotes, KIF6 719Arg carriers were not at significantly higher risk for non-fatal MI in this study after adjustment for traditional risk factors or admixture (OR=1.12; 95%CI, 0.98-1.28). Heterozygotes of the KIF6 Trp719Arg variant were at increased risk of non-fatal MI: the adjusted odds ratio was 1.16 (95% confidence interval, 1.01-1.34), but this association would not be significant after a multiple testing correction. CONCLUSIONS/SIGNIFICANCE. We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica. en_US
dc.description.sponsorship National Institutes of Health (HL49086, HL60692); American Heart Association (0625819T) en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights Bare et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.title Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population en_US
dc.type article en_US
dc.identifier.doi 10.1371/journal.pone.0013081 en_US
dc.identifier.pubmedid 20927332 en_US
dc.identifier.pmcid 2947524 en_US

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