The Origin and Evolution of the Ribosome

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dc.contributor.author Smith, Temple F en_US
dc.contributor.author Lee, Jung C en_US
dc.contributor.author Gutell, Robin R en_US
dc.contributor.author Hartman, Hyman en_US
dc.date.accessioned 2012-01-12T17:46:41Z
dc.date.available 2012-01-12T17:46:41Z
dc.date.copyright 2008 en_US
dc.date.issued 2008-4-22 en_US
dc.identifier.citation Smith, Temple F, Jung C Lee, Robin R Gutell, Hyman Hartman. "The origin and evolution of the ribosome" Biology Direct 3:16. (2008) en_US
dc.identifier.issn 1745-6150 en_US
dc.identifier.uri http://hdl.handle.net/2144/3439
dc.description.abstract BACKGROUND. The origin and early evolution of the active site of the ribosome can be elucidated through an analysis of the ribosomal proteins' taxonomic block structures and their RNA interactions. Comparison between the two subunits, exploiting the detailed three-dimensional structures of the bacterial and archaeal ribosomes, is especially informative. RESULTS. The analysis of the differences between these two sites can be summarized as follows: 1) There is no self-folding RNA segment that defines the decoding site of the small subunit; 2) there is one self-folding RNA segment encompassing the entire peptidyl transfer center of the large subunit; 3) the protein contacts with the decoding site are made by a set of universal alignable sequence blocks of the ribosomal proteins; 4) the majority of those peptides contacting the peptidyl transfer center are made by bacterial or archaeal-specific sequence blocks. CONCLUSION. These clear distinctions between the two subunit active sites support an earlier origin for the large subunit's peptidyl transferase center (PTC) with the decoding site of the small subunit being a later addition to the ribosome. The main implications are that a single self-folding RNA, in conjunction with a few short stabilizing peptides, formed the precursor of the modern ribosomal large subunit in association with a membrane. REVIEWERS. This article was reviewed by Jerzy Jurka, W. Ford Doolittle, Eugene Shaknovich, and George E. Fox (nominated by Jerzy Jurka). en_US
dc.description.sponsorship National Science Foundation (DBI-051600); National Institutes of Health (GM067317); Welch Foundation (F1427) en_US
dc.language.iso en en_US
dc.publisher BioMed Central en_US
dc.rights Copyright 2008 Smith et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. en_US
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_US
dc.title The Origin and Evolution of the Ribosome en_US
dc.type article en_US
dc.identifier.doi 10.1186/1745-6150-3-16 en_US
dc.identifier.pubmedid 18430223 en_US
dc.identifier.pmcid 2386862 en_US

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