Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics


Show simple item record Fortier, Catherine Brawn en_US Maksimovskiy, Arkadiy L. en_US Venne, Jonathan R. en_US LaFleche, Ginette en_US McGlinchey, Regina E. en_US 2012-01-12T17:50:13Z 2012-01-12T17:50:13Z 2009 en_US 2009-7-20 en_US
dc.identifier.citation Fortier, Catherine Brawn, Arkadiy L. Maksimovskiy, Jonathan R. Venne, Ginette LaFleche, Regina E. McGlinchey. "Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics" International Journal of Environmental Research and Public Health 6(7): 2007-2027. (2009) en_US
dc.identifier.issn 1660-4601 en_US
dc.description.abstract Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics' impairment in flexibly altering learned associations may be central to their continued addiction. en_US
dc.description.sponsorship National Istitute of Health (NIAAA 14205) en_US
dc.language.iso en en_US
dc.publisher Molecular Diversity Preservation International (MDPI) en_US
dc.rights Copyright 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. en_US
dc.rights.uri en_US
dc.subject Alcohol en_US
dc.subject Eyeblink classical conditioning en_US
dc.subject Learning en_US
dc.subject Discrimination en_US
dc.subject Reversal en_US
dc.title Silent Trace Eliminates Differential Eyeblink Learning in Abstinent Alcoholics en_US
dc.type article en_US
dc.identifier.doi 10.3390/ijerph6072007 en_US
dc.identifier.pubmedid 19742168 en_US
dc.identifier.pmcid 2738895 en_US

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