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Browsing College of Arts and Sciences by Author "Finnerty, John R"

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The Cnidarian-Bilaterian Ancestor Possessed at Least 56 Homeoboxes: Evidence from the Starlet Sea Anemone, Nematostella vectensis

Ryan, Joseph F; Burton, Patrick M; Mazza, Maureen E; Kwong, Grace K; Mullikin, James C; Finnerty, John R (BioMed Central, 2006-07-24)

The first near-complete set of homeodomains from a non-bilaterian animal is described. BACKGROUND. Homeodomain transcription factors are key components in the developmental toolkits of animals. While this gene superclass ...
A Conserved Cluster of Three PRD-class Homeobox Genes (Homeobrain, Rx and Orthopedia) in the Cnidaria and Protostomia

Mazza, Maureen E; Pang, Kevin; Reitzel, Adam M; Martindale, Mark Q; Finnerty, John R (BioMed Central, 2010-07-05)

BACKGROUND. Homeobox genes are a superclass of transcription factors with diverse developmental regulatory functions, which are found in plants, fungi and animals. In animals, several Antennapedia (ANTP)-class homeobox ...
Domain Duplication, Divergence, and Loss Events in Vertebrate Msx Paralogs Reveal Phylogenomically Informed Disease Markers

Finnerty, John R; Mazza, Maureen E; Jezewski, Peter A (BioMed Central, 2009-1-20)

BACKGROUND. Msx originated early in animal evolution and is implicated in human genetic disorders. To reconstruct the functional evolution of Msx and inform the study of human mutations, we analyzed the phylogeny and synteny ...
The Evolutionary Diversification of LSF and Grainyhead Transcription Factors Preceded the Radiation of Basal Animal Lineages

Traylor-Knowles, Nikki; Hansen, Ulla; Dubuc, Timothy Q; Martindale, Mark Q; Kaufman, Les; Finnerty, John R (BioMed Central, 2010-4-18)

BACKGROUND. The transcription factors of the LSF/Grainyhead (GRH) family are characterized by the possession of a distinctive DNA-binding domain that bears no clear relationship to other known DNA-binding domains, with the ...
The Evolutionary Origin of the Runx/CBFbeta Transcription Factors – Studies of the Most Basal Metazoans

Sullivan, James C; Sher, Daniel; Eisenstein, Miriam; Shigesada, Katsuya; Reitzel, Adam M; Marlow, Heather; Levanon, Ditsa; Groner, Yoram; Finnerty, John R; Gat, Uri (BioMed Central, 2008-8-5)

BACKGROUND. Members of the Runx family of transcriptional regulators, which bind DNA as heterodimers with CBFβ, are known to play critical roles in embryonic development in many triploblastic animals such as mammals and ...

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Browsing College of Arts and Sciences by Author "Finnerty, John R"

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