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  • A Genome-Wide Association Study of Pulmonary Function Measures in the Framingham Heart Study
    Wilk, Jemma B.; Chen, Ting-hsu; Gottlieb, Daniel J.; Walter, Robert E.; Nagle, Michael W.; Brandler, Brian J.; Myers, Richard H.; Borecki, Ingrid B.; Silverman, Edwin K.; Weiss, Scott T.; O'Connor, George T. (Public Library of Science, 2009-3-20)
    The ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) is a measure used to diagnose airflow obstruction and is highly heritable. We performed a genome-wide association study in 7,691 ...
  • Genome-Wide Association to Body Mass Index and Waist Circumference: The Framingham Heart Study 100K Project
    Fox, Caroline S; Heard-Costa, Nancy; Cupples, L Adrienne; Dupuis, Josée; Vasan, Ramachandran S; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures ...
  • Genome-Wide Association with Bone Mass and Geometry in the Framingham Heart Study
    Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Genome-Wide Association with Select Biomarker Traits in the Framingham Heart Study
    Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Genome-Wide Linkage Analysis for Alcohol Dependence: A Comparison between Single-Nucleotide Polymorphism and Microsatellite Marker Assays
    Ma, Qianli; Yu, Yi; Meng, Yan; Farrell, John; Farrer, Lindsay A; Wilcox, Marsha A (BioMed Central, 2005-12-30)
    Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we ...
  • Genome-Wide Screen for Heavy Alcohol Consumption
    Wyszynski, Diego F; Panhuysen, Carolien I; Ma, Qianli; Yip, Agustin G; Wilcox, Marsha; Erlich, Porat; Farrer, Lindsay A (BioMed Central, 2003-12-31)
    BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected ...
  • Genome-Wide Significance for a Modifier of Age at Neurological Onset in Huntington's Disease at 6q23-24: The HD MAPS Study
    Li, Jian-Liang; Hayden, Michael R; Warby, Simon C; Durr, Alexandra; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Rosenblatt, Adam; Squitieri, Ferdinando; Frati, Luigi; Gómez-Tortosa, Estrella; García, Carmen Ayuso; Suchowersky, Oksana; Klimek, Mary Lou; Trent, Ronald JA; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Paulsen, Jane S; Jones, Randi; Ashizawa, Tetsuo; Lazzarini, Alice; Wheeler, Vanessa C; Prakash, Ranjana; Xu, Gang; Djoussé, Luc; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Hakky, Michael; Cupples, L Adrienne; Saint-Hilaire, Marie H; Cha, Jang-Ho J; Hersch, Steven M; Penney, John B; Harrison, Madaline B; Perlman, Susan L; Zanko, Andrea; Abramson, Ruth K; Lechich, Anthony J; Duckett, Ayana; Marder, Karen; Conneally, P Michael; Gusella, James F; MacDonald, Marcy E; Myers, Richard H (BioMed Central, 2006-8-17)
    BACKGROUND: Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to ...
  • Giant Organ Confined Prostatic Adenocarcinoma: A Case Report
    Brahmbhatt, Jamin V; Liou, Louis S (BioMed Central, 2008-1-29)
    INTRODUCTION Giant prostatic adenocarcinoma represents a rare and challenging treatment dilemma. CASE PRESENTATION We describe a case of an otherwise healthy 71-year-old African male who presented with a PSA of 5800 ng/ml ...
  • Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer
    Chatterjee, Aparajita; Carpentieri, Andrea; Ratner, Daniel M.; Bullitt, Esther; Costello, Catherine E.; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2010-8-19)
    The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or G. duodenalis) is the cyst. The Giardia cyst wall contains fibrils of a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer ...
  • The Global Pediatric Antiretroviral Market: Analyses of Product Availability and Utilization Reveal Challenges for Development of Pediatric Formulations and HIV/AIDS Treatment in Children
    Waning, Brenda; Diedrichsen, Ellen; Jambert, Elodie; Bärnighausen, Till; Li, Yun; Pouw, Mieke; Moon, Suerie (BioMed Central, 2010-10-17)
    BACKGROUND: Important advances in the development and production of quality-certified pediatric antiretroviral (ARV) formulations have recently been made despite significant market disincentives for manufacturers. This ...
  • The Gly2019Ser Mutation in LRRK2 Is not Fully Penetrant in Familial Parkinson's Disease: The GenePD Study
    Latourelle, Jeanne C; Sun, Mei; Lew, Mark F; Suchowersky, Oksana; Klein, Christine; Golbe, Lawrence I; Mark, Margery H; Growdon, John H; Wooten, G Frederick; Watts, Ray L; Guttman, Mark; Racette, Brad A; Perlmutter, Joel S; Ahmed, Anwar; Shill, Holly A; Singer, Carlos; Goldwurm, Stefano; Pezzoli, Gianni; Zini, Michela; Saint-Hilaire, Marie H; Hendricks, Audrey E; Williamson, Sally; Nagle, Michael W; Wilk, Jemma B; Massood, Tiffany; Huskey, Karen W; Laramie, Jason M; DeStefano, Anita L; Baker, Kenneth B; Itin, Ilia; Litvan, Irene; Nicholson, Garth; Corbett, Alastair; Nance, Martha; Drasby, Edward; Isaacson, Stuart; Burn, David J; Chinnery, Patrick F; Pramstaller, Peter P; Al-hinti, Jomana; Moller, Anette T; Ostergaard, Karen; Sherman, Scott J; Roxburgh, Richard; Snow, Barry; Slevin, John T; Cambi, Franca; Gusella, James F; Myers, Richard H (BioMed Central, 2008-11-5)
    BACKGROUND: We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser ...
  • Healthcare Costs and Utilization for Medicare Beneficiaries with Alzheimer's
    Zhao, Yang; Kuo, Tzu-Chun; Weir, Sharada; Kramer, Marilyn S; Ash, Arlene S (BioMed Central, 2008-5-22)
    BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder incurring significant social and economic costs. This study uses a US administrative claims database to evaluate the effect of AD on direct healthcare ...
  • Hematopoietic Gene Promoters Subjected to a Group-Combinatorial Study of DNA Samples: Identification of a Megakaryocytic Selective DNA Signature
    Hazony, Yehonathan; Lu, Jun; St. Hilaire, Cynthia; Ravid, Katya (Oxford University Press, 2006-08-26)
    Identification of common sub-sequences for a group of functionally related DNA sequences can shed light on the role of such elements in cell-specific gene expression. In the megakaryocytic lineage, no one single unique ...
  • HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
    Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010-09)
    BACKGROUND. Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...
  • A Hierarchical and Modular Approach to the Discovery of Robust Associations in Genome-Wide Association Studies from Pooled DNA Samples
    Sebastiani, Paola; Zhao, Zhenming; Abad-Grau, Maria M; Riva, Alberto; Hartley, Stephen W; Sedgewick, Amanda E; Doria, Alessandro; Montano, Monty; Melista, Efthymia; Terry, Dellara; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T (BioMed Central, 2008-1-14)
    BACKGROUND: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. RESULTS. We present a ...
  • High Density Lipoproteins-Based Therapies for Cardiovascular Disease
    Gao, Xuan; Yuan, Shujun (Medknow Publications, 2010-07)
    Atherosclerosis is the leading cause of death in developed countries. High density lipoproteins (HDL) cholesterol level correlates inversely with the risk of cardiovascular diseases. Thus, HDL has obtained lots of interest ...
  • High Quality Care and Ethical Pay-for-Performance: A Society of General Internal Medicine Policy Analysis
    Wharam, J. Frank; Paasche-Orlow, Michael K.; Farber, Neil J.; Sinsky, Christine; Rucker, Lisa; Rask, Kimberly J.; Figaro, M. Kathleen; Braddock, Clarence; Barry, Michael J.; Sulmasy, Daniel P. (Springer-Verlag, 2009-3-18)
    BACKGROUND Pay-for-performance is proliferating, yet its impact on key stakeholders remains uncertain. OBJECTIVE The Society of General Internal Medicine systematically evaluated ethical issues raised by performance-based ...
  • HIV-Associated Primary Lung Cancer (LC) in the Era of Highly Active Antiretroviral Therapy (HAART): A Multi-Institutional Collaboration
    D'Jaen, Gabriela; Pantanowitz, Liron; Bower, Mark; Buskin, Susan; Neil, Nancy; Greco, Erin; Cooley, Timothy; Henry, David; Stem, Jonathan; Dezube, Bruce; Stebbing, Justin; Aboulafia, David (BioMed Central, 2010-10-11)
  • How good is the orthopaedic literature?
    Chaudhry, Harman; Mundi, Raman; Singh, Ishu; Einhorn, Thomas A.; Bhandari, Mohit (Medknow Publications, 2008-04)
    Randomized trials constitute approximately 3% of the orthopaedic literature Concerns regarding quality of the orthopaedic literature stem from a widespread notion that the overall quality of the surgical literature is in ...
  • Human Immunodeficiency Virus Type-1 Episomal cDNA in Semen
    Xu, Chong; Politch, Joseph A; Mayer, Kenneth H; Anderson, Deborah J (BioMed Central, 2005-10-11)
    BACKGROUND. Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor cryptic ...

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