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  • A Multilevel Intervention to Promote Colorectal Cancer Screening among Community Health Center Patients: Results of a Pilot Study
    Lasser, Karen E; Murillo, Jennifer; Medlin, Elizabeth; Lisboa, Sandra; Valley-Shah, Lisa; Fletcher, Robert H; Emmons, Karen M; Ayanian, John Z (BioMed Central, 2009-5-29)
    BACKGROUND. Colorectal cancer screening rates are low among poor and disadvantaged patients. Patient navigation has been shown to increase breast and cervical cancer screening rates, but few studies have looked at the ...
  • Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
    Saccone, Nancy L.; Culverhouse, Robert C.; Schwantes-An, Tae-Hwi; Cannon, Dale S.; Chen, Xiangning; Cichon, Sven; Giegling, Ina; Han, Shizhong; Han, Younghun; Keskitalo-Vuokko, Kaisu; Kong, Xiangyang; Landi, Maria Teresa; Ma, Jennie Z.; Short, Susan E.; Stephens, Sarah H.; Stevens, Victoria L.; Sun, Lingwei; Wang, Yufei; Wenzlaff, Angela S.; Aggen, Steven H.; Breslau, Naomi; Broderick, Peter; Chatterjee, Nilanjan; Chen, Jingchun; Heath, Andrew C.; Heliövaara, Markku; Hoft, Nicole R.; Hunter, David J.; Jensen, Majken K.; Martin, Nicholas G.; Montgomery, Grant W.; Niu, Tianhua; Payne, Thomas J.; Peltonen, Leena; Pergadia, Michele L.; Rice, John P.; Sherva, Richard; Spitz, Margaret R.; Sun, Juzhong; Wang, Jen C.; Weiss, Robert B.; Wheeler, William; Witt, Stephanie H.; Yang, Bao-Zhu; Caporaso, Neil E.; Ehringer, Marissa A.; Eisen, Tim; Gapstur, Susan M.; Gelernter, Joel; Houlston, Richard; Kaprio, Jaakko; Kendler, Kenneth S.; Kraft, Peter; Leppert, Mark F.; Li, Ming D.; Madden, Pamela A. F.; Nöthen, Markus M.; Pillai, Sreekumar; Rietschel, Marcella; Rujescu, Dan; Schwartz, Ann; Amos, Christopher I.; Bierut, Laura J. (Public Library of Science, 2010-8-5)
    Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic ...
  • MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes
    Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Gygi, Steven P.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G. (The Rockefeller University Press, 2009-06-22)
    Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now ...
  • Mutations in the Paralogous Human α-globin Genes Yielding Identical Hemoglobin Variants
    Moradkhani, Kamran; Préhu, Claude; Old, John; Henderson, Shirley; Balamitsa, Vera; Luo, Hong-Yuan; Poon, Man-Chiu; Chui, David H. K.; Wajcman, Henri; Patrinos, George P. (Springer-Verlag, 2008-10-16)
    The human α-globin genes are paralogues, sharing a high degree of DNA sequence similarity and producing an identical α-globin chain. Over half of the α-globin structural variants reported to date are only characterized at ...
  • National Survey of Patients' Bill of Rights Statutes
    Paasche-Orlow, Michael K.; Jacob, Dan M.; Hochhauser, Mark; Parker, Ruth M. (Springer-Verlag, 2009-2-3)
    BACKGROUND Despite vigorous national debate between 1999–2001 the federal patients' bill of rights (PBOR) was not enacted. However, states have enacted legislation and the Joint Commission defined an accreditation standard ...
  • Natural Variation of the Amino-Terminal Glutamine-Rich Domain in Drosophila Argonaute2 Is Not Associated with Developmental Defects
    Hain, Daniel; Bettencourt, Brian R.; Okamura, Katsutomo; Csorba, Tibor; Meyer, Wibke; Jin, Zhigang; Biggerstaff, Jason; Siomi, Haruhiko; Hutvagner, Gyorgy; Lai, Eric C.; Welte, Michael; Müller, H.-Arno J. (Public Library of Science, 2010-12-17)
    The Drosophila argonaute2 (ago2) gene plays a major role in siRNA mediated RNA silencing pathways. Unlike mammalian Argonaute proteins, the Drosophila protein has an unusual amino-terminal domain made up largely of multiple ...
  • Neurologic Factors in Female Sexual Function and Dysfunction
    Azadzoi, Kazem M.; Siroky, Mike B. (The Korean Urological Association, 2010-7-20)
    Sexual dysfunction affects both men and women, involving organic disorders, psychological problems, or both. Overall, the state of our knowledge is less advanced regarding female sexual physiology in comparison with male ...
  • NFIA Haploinsufficiency Is Associated with a CNS Malformation Syndrome and Urinary Tract Defects
    Lu, Weining; Quintero-Rivera, Fabiola; Fan, Yanli; Alkuraya, Fowzan S; Donovan, Diana J; Xi, Qiongchao; Turbe-Doan, Annick; Li, Qing-Gang; Campbell, Craig G; Shanske, Alan L; Sherr, Elliott H; Ahmad, Ayesha; Peters, Roxana; Rilliet, Benedict; Parvex, Paloma; Bassuk, Alexander G; Harris, David J; Ferguson, Heather; Kelly, Chantal; Walsh, Christopher A; Gronostajski, Richard M; Devriendt, Koenraad; Higgins, Anne; Ligon, Azra H; Quade, Bradley J; Morton, Cynthia C; Gusella, James F; Maas, Richard L (Public Library of Science, 2007-5-25)
    Complex central nervous system (CNS) malformations frequently coexist with other developmental abnormalities, but whether the associated defects share a common genetic basis is often unclear. We describe five individuals ...
  • Nicotinic Acetylcholine Receptor Subunit Variants Are Associated with Blood Pressure; Findings in the Old Order Amish and Replication in the Framingham Heart Study
    McArdle, Patrick F; Rutherford, Sue; Mitchell, Braxton D; Damcott, Coleen M; Wang, Ying; Ramachandran, Vasan; Ott, Sandy; Chang, Yen-Pei C; Levy, Daniel; Steinle, Nanette (BioMed Central, 2008-7-14)
    BACKGROUND: Systemic blood pressure, influenced by both genetic and environmental factors, is regulated via sympathetic nerve activity. We assessed the role of genetic variation in three subunits of the neuromuscular ...
  • Noninvasive Assessment of Antenatal Hydronephrosis in Mice Reveals a Critical Role for Robo2 in Maintaining Anti-Reflux Mechanism
    Wang, Hang; Li, Qinggang; Liu, Juan; Mendelsohn, Cathy; Salant, David J.; Lu, Weining (PLoS ONE, 2011-09-20)
    Antenatal hydronephrosis and vesicoureteral reflux (VUR) are common renal tract birth defects. We recently showed that disruption of the Robo2 gene is associated with VUR in humans and antenatal hydronephrosis in knockout ...
  • Nonlinear Modeling of Venous Leg Ulcer Healing Rates
    Cardinal, Matthew; Phillips, Tania; Eisenbud, David E; Harding, Keith; Mansbridge, Jonathan; Armstrong, David G (BioMed Central, 2009-3-31)
    BACKGROUND. The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics. METHODS. We studied 3,588 serial wound tracings of 338 venous ...
  • Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease Risk: The MIRAGE Study
    Yip, Agustín G; Green, Robert C; Huyck, Matthew; Cupples, L Adrienne; Farrer, Lindsay A (BioMed Central, 2005-1-12)
    BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID) use may protect against Alzheimer's disease (AD) risk. We sought examine the association between NSAID use and risk of AD, and potential effect modification by APOE-ε4 ...
  • NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium
    Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • An Obesity Dietary Quality Index Predicts Abdominal Obesity in Women: Potential Opportunity for New Prevention and Treatment Paradigms
    Wolongevicz, Dolores M.; Zhu, Lei; Pencina, Michael J.; Kimokoti, Ruth W.; Newby, P. K.; D'Agostino, Ralph B.; Millen, Barbara E. (Hindawi Publishing Corporation, 2010-1-5)
    Background. Links between dietary quality and abdominal obesity are poorly understood. Objective. To examine the association between an obesity-specific dietary quality index and abdominal obesity risk in women. Methods. ...
  • On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies
    Won, Sungho; Wilk, Jemma B.; Mathias, Rasika A.; O'Donnell, Christopher J.; Silverman, Edwin K.; Barnes, Kathleen; O'Connor, George T.; Weiss, Scott T.; Lange, Christoph (Public Library of Science, 2009-11-26)
    For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ...
  • Oral Clefts with Associated Anomalies: Findings in the Hungarian Congenital Abnormality Registry
    Sárközi, Andrea; Wyszynski, Diego F; Czeizel, Andrew E (BioMed Central, 2005-6-28)
    BACKGROUND: Over the years, great efforts have been made to record the frequency of orofacial clefts in different populations. However, very few studies were able to account for the etiological and phenotypic heterogeneity ...
  • Oral Tolerance Inhibits Pulmonary Eosinophilia in a Cockroach Allergen Induced Model of Asthma: A Randomized Laboratory Study
    Vaickus, Louis J; Bouchard, Jacqueline; Kim, Jiyoun; Natarajan, Sudha; Remick, Daniel G (BioMed Central, 2010-11-23)
    BACKGROUND. Antigen desensitization through oral tolerance is becoming an increasingly attractive treatment option for allergic diseases. However, the mechanism(s) by which tolerization is achieved remain poorly defined. ...
  • The Orthopaedic Trauma Literature: An Evaluation of Statistically Significant Findings in Orthopaedic Trauma Randomized Trials
    Sung, Jinsil; Siegel, Judith; Tornetta, Paul; Bhandari, Mohit (BioMed Central, 2008-1-29)
    BACKGROUND.: Evidence-based medicine posits that health care research is founded upon clinically important differences in patient centered outcomes. Statistically significant differences between two treatments may not ...
  • Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein
    Zerbinatti, Celina V; Cordy, Joanna M; Chen, Ci-Di; Guillily, Maria; Suon, Sokreine; Ray, William J; Seabrook, Guy R; Abraham, Carmela R; Wolozin, Benjamin (BioMed Central, 2008-3-18)
    BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ...
  • P05-10. Sequential Immunization with a Subtype B HIV-1 Envelope Quasispecies Elicits Broader Neutralization than Vaccination with a Single Envelope Clone
    Malherbe, DC; Doria-Rose, N; Misher, L; Beckett, T; Blay-Puryear, W; Barnett, S; Srivastava, I; Richardson, B; Stamatatos, L; Haigwood, NL (BioMed Central, 2009-10-22)

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