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  • Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus
    Valmas, Charalampos; Grosch, Melanie N.; Schümann, Michael; Olejnik, Judith; Martinez, Osvaldo; Best, Sonja M.; Krähling, Verena; Basler, Christopher F.; Mühlberger, Elke (Public Library of Science, 2010-1-15)
    Previous studies have demonstrated that Marburg viruses (MARV) and Ebola viruses (EBOV) inhibit interferon (IFN)-α/β signaling but utilize different mechanisms. EBOV inhibits IFN signaling via its VP24 protein which blocks ...
  • Measurement of Treatment Adherence with Antipsychotic Agents in Patients with Schizophrenia
    Ren, Xinhua S; Herz, Lawrence; Qian, Shirley; Smith, Eric; Kazis, Lewis E (Dove Medical Press, 2009-10-12)
    The importance of medication adherence in sustaining control of schizophrenic symptoms has generated a great deal of interest in comparing levels of treatment adherence with different antipsychotic agents. However, the ...
  • Mechanisms in Bradykinin Stimulated Arachidonate Release and Synthesis of Prostaglandin and Platelet Activating Factor
    Ricupero, D.; Taylor, L.; Tlucko, A.; Navarro, J.; Polgar, P. (Hindawi Publishing Corporation, 1982)
    Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...
  • Metabolic Constraints on the Recovery of Sensitivity after Visual Pigment Bleaching in Retinal Rods
    Miyagishima, Kiyoharu J.; Cornwall, M. Carter; Sampath, Alapakkam P. (The Rockefeller University Press, 2009-08-17)
    The shutoff of active intermediates in the phototransduction cascade and the reconstitution of the visual pigment play key roles in the recovery of sensitivity after the exposure to bright light in both rod and cone ...
  • Metabolic Profiling of the Human Response to a Glucose Challenge Reveals Distinct Axes of Insulin Sensitivity
    Shaham, Oded; Wei, Ru; Wang, Thomas J; Ricciardi, Catherine; Lewis, Gregory D; Vasan, Ramachandran S; Carr, Steven A; Thadhani, Ravi; Gerszten, Robert E; Mootha, Vamsi K (Nature Publishing GroupMolecular Systems Biology, 2008-08-05)
    Glucose ingestion after an overnight fast triggers an insulin-dependent, homeostatic program that is altered in diabetes. The full spectrum of biochemical changes associated with this transition is currently unknown. We ...
  • Method for Inducing Experimental Pneumococcal Meningitis in Outbred Mice
    Chiavolini, Damiana; Tripodi, Sergio; Parigi, Riccardo; Oggioni, Marco R; Blasi, Elisabetta; Cintorino, Marcella; Pozzi, Gianni; Ricci, Susanna (BioMed Central, 2004-9-22)
    BACKGROUND: Streptococcus pneumoniae is the leading cause of bacterial meningitis. Pneumococcal meningitis is associated with the highest mortality among bacterial meningitis and it may also lead to neurological sequelae ...
  • Microarray Gene Expression Profiling and Analysis in Renal Cell Carcinoma
    Liou, Louis S; Shi, Ting; Duan, Zhong-Hui; Sadhukhan, Provash; Der, Sandy D; Novick, Andrew A; Hissong, John; Skacel, Marek; Almasan, Alexandru; DiDonato, Joseph A (BioMed Central, 2004-6-22)
    BACKGROUND. Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the disease are limited by the ...
  • Migraine and Risk of Haemorrhagic Stroke in Women: Prospective Cohort Study
    Kurth, Tobias; Kase, Carlos S; Schürks, Markus; Tzourio, Christophe; Buring, Julie E (BMJ Publishing Group Ltd., 2010-8-24)
    Objectives To examine the association between migraine and migraine aura status with risk of haemorrhagic stroke. Design Prospective cohort study. Setting Women's Health Study, United States. Participants 27860 women aged ...
  • Migraine, Fibromyalgia, and Depression among People with IBS: A Prevalence Study
    Cole, J Alexander; Rothman, Kenneth J; Cabral, Howard J; Zhang, Yuqing; Farraye, Francis A (BioMed Central, 2006-9-28)
    BACKGROUND. Case descriptions suggest IBS patients are more likely to have other disorders, including migraine, fibromyalgia, and depression. We sought to examine the prevalence of these conditions in cohorts of people ...
  • Minimal and Direct Access Surgery in Urology
    Repassy, D. L.; Frang, D.; Jako, G. J. (Hindawi Publishing Corporation, 2011-12-29)
    An alternative method to laparoscopic surgery has been developed for urological procedures. The surgery is minimal access because the length of the single skin incision ranges from 3–6 cm depending on the type of operation. ...
  • Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis
    Molina, Anthony J.A.; Wikstrom, Jakob D.; Stiles, Linsey; Las, Guy; Mohamed, Hibo; Elorza, Alvaro; Walzer, Gil; Twig, Gilad; Katz, Steve; Corkey, Barbara E.; Shirihai, Orian S. (American Diabetes Association, 2009-7-6)
    OBJECTIVE: Previous studies have reported that β-cell mitochondria exist as discrete organelles that exhibit heterogeneous bioenergetic capacity. To date, networking activity, and its role in mediating β-cell mitochondrial ...
  • A Model for Transient Oxygen Delivery in Cerebral Cortex
    Ress, David; Thompson, Jeffrey K.; Rokers, Bas; Khan, Reswanul K.; Huk, Alexander C. (Frontiers Research Foundation, 2009-06-29)
    Popular hemodynamic brain imaging methods, such as blood oxygen-level dependent functional magnetic resonance imaging (BOLD fMRI), would benefit from a detailed understanding of the mechanisms by which oxygen is delivered ...
  • Modifying Effects of the HFE Polymorphisms on the Association between Lead Burden and Cognitive Decline
    Wang, Florence T.; Hu, Howard; Schwartz, Joel; Weuve, Jennifer; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin K.; Weiss, Scott T.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. OBJECTIVE. ...
  • Modulation of Adipocyte Lipogenesis by Octanoate: Involvement of Reactive Oxygen Species
    Guo, Wen; Xie, Weisheng; Han, Jianrong (BioMed Central, 2006-7-27)
    BACKGROUND. Octanoate is a medium-chain fatty acid (MCFA) that is rich in milk and tropical dietary lipids. It also accounts for 70% of the fatty acids in commercial medium chain triglycerides (MCT). Use of MCT for weight ...
  • Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease
    Kao, Patricia F.; Davis, David A.; Banigan, Meredith G.; Vanderburg, Charles R.; Seshadri, Sudha; Delalle, Ivana (Public Library of Science, 2010-10-13)
    During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites ...
  • Molecular Model of the Microvillar Cytoskeleton and Organization of the Brush Border
    Brown, Jeffrey W.; McKnight, C. James (Public Library of Science, 2010-2-24)
    BACKGROUND. Brush border microvilli are ~1-µm long finger-like projections emanating from the apical surfaces of certain, specialized absorptive epithelial cells. A highly symmetric hexagonal array of thousands of these ...
  • Molecular Weight Assessment of Proteins in Total Proteome Profiles using 1D-PAGE and LC/MS/MS
    Ahmad, Q Rushdy; Nguyen, Dat H; Wingerd, Mark A; Church, George M; Steffen, Martin A (BioMed Central, 2005-6-8)
    BACKGROUND. The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ...
  • MRI and Neuropsychological Correlates of Carbon Monoxide Exposure: A Case Report
    Devine, Sherral A; Kirkley, Shalene M; Palumbo, Carole L; White, Roberta F (National Institute of Environmental Health Sciences, 2002-10)
    A 45-year-old woman experienced long-term, chronic exposure to carbon monoxide in the restaurant kitchen where she was employed as a cook. After returning to the restaurant after 5 days off work, she noticed that her ...
  • MRI Parameters Of Alzheimer's Disease in an Arab Population of Wadi Ara, Israel
    Bowirrat, Abdalla; Reider-Groswasser, Irith I; Oscar-Berman, Marlene; Aizenstein, Orna; Levy, Gad; Korczyn, Amos D (Dove Medical Press, 2005)
    Magnetic resonance imaging (MRI) findings are reported from 15 individuals in an Arab–Israeli community who were diagnosed with Alzheimer's disease (AD). The quantitative parameters that were used for MRI analyses included ...
  • Multifactor-Dimensionality Reduction Versus Family-Based Association Tests in Detecting Susceptibility Loci in Discordant Sib-Pair Studies
    Meng, Yan; Ma, Qianli; Yu, Yi; Farrell, John; Farrer, Lindsay A; Wilcox, Marsha A (BioMed Central, 2005-12-30)
    Complex diseases are generally thought to be under the influence of multiple, and possibly interacting, genes. Many association methods have been developed to identify susceptibility genes assuming a single-gene disease ...

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