Browsing School of Medicine by Subject "Epidemiology"

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Browsing School of Medicine by Subject "Epidemiology"

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  • Association of Cumulative Lead Exposure with Parkinson's Disease
    Weisskopf, Marc G.; Weuve, Jennifer; Nie, Huiling; Saint-Hilaire, Marie-Helene; Sudarsky, Lewis; Simon, David K.; Hersh, Bonnie; Schwartz, Joel; Wright, Robert O.; Hu, Howard (National Institute of Environmental Health Sciences, 2010-11)
    BACKGROUND. Research using reconstructed exposure histories has suggested an association between heavy metal exposures, including lead, and Parkinson's disease (PD), but the only study that used bone lead, a biomarker of ...
  • Black Carbon Exposure, Oxidative Stress Genes, and Blood Pressure in a Repeated-Measures Study
    Mordukhovich, Irina; Wilker, Elissa; Suh, Helen; Wright, Robert; Sparrow, David; Vokonas, Pantel S.; Schwartz, Joel (National Institute of Environmental Health Sciences, 2009-11)
    BACKGROUND. Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies ...
  • Cumulative Community-Level Lead Exposure and Pulse Pressure: The Normative Aging Study
    Perlstein, Todd; Weuve, Jennifer; Schwartz, Joel; Sparrow, David; Wright, Robert; Litonjua, Augusto; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-12)
    BACKGROUND. Pulse pressure increases with age in industrialized societies as a manifestation of arterial stiffening. Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote ...
  • The Epidemiology and Management of Severe Hypertension
    Borzecki, A M; Kader, B; Berlowitz, D R (Nature Publishing Group, 2009-05-14)
    Hypertension guidelines stress that patients with severe hypertension (systolic blood pressure (BP)⩾180 or diastolic BP⩾110mmHg) require multiple drugs to achieve control and should have close follow-up to prevent adverse ...
  • Lead Levels and Ischemic Heart Disease in a Prospective Study of Middle-Aged and Elderly Men: the VA Normative Aging Study
    Jain, Nitin B.; Potula, Vijayalakshmi; Schwartz, Joel; Vokonas, Pantel S.; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-06)
    BACKGROUND. Lead exposure has been associated with higher blood pressure, hypertension, electrocardiogram abnormalities, and increased mortality from circulatory causes. OBJECTIVE. We assessed the association between bone ...
  • Modifying Effects of the HFE Polymorphisms on the Association between Lead Burden and Cognitive Decline
    Wang, Florence T.; Hu, Howard; Schwartz, Joel; Weuve, Jennifer; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin K.; Weiss, Scott T.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. OBJECTIVE. ...
  • Potential Misinterpretations Caused by Collapsing Upper Categories of Comorbidity Indices: An Illustration from a Cohort of Older Breast Cancer Survivors
    Ahern, Thomas P; Bosco, Jaclyn LF; Silliman, Rebecca A; Yood, Marianne Ulcickas; Field, Terry S; Wei, Feifei; Lash, Timothy L (Dove Medical Press, 2009-8-9)
    BACKGROUND: Comorbidity indices summarize complex medical histories into concise ordinal scales, facilitating stratification and regression in epidemiologic analyses. Low subject prevalence in the highest strata of a ...
  • Role of the Neurologist in Hazard Identification and Risk Assessment
    Feldman, R G; White, R F (National Institute of Environmental Health Sciences, 1996-04)
    This review describes strategies used by a clinical neurologist in the investigation of neurotoxic disease. It emphasizes the need for a high level of suspicion that environmental substances are capable of producing ...

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