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Browsing Basic Science by Title

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  • Wolozin, Benjamin; Wang, Stanley W; Li, Nien-Chen; Lee, Austin; Lee, Todd A; Kazis, Lewis E (BioMed Central, 2007-7-19)
    BACKGROUND: Statins are a class of medications that reduce cholesterol by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Whether statins can benefit patients with dementia remains unclear because of conflicting ...
  • Sridhar, Sriram; Schembri, Frank; Zeskind, Julie; Shah, Vishal; Gustafson, Adam M; Steiling, Katrina; Liu, Gang; Dumas, Yves-Martine; Zhang, Xiaohui; Brody, Jerome S; Lenburg, Marc E; Spira, Avrum (BioMed Central, 2008-5-30)
    BACKGROUND: Cigarette smoking is a leading cause of preventable death and a significant cause of lung cancer and chronic obstructive pulmonary disease. Prior studies have demonstrated that smoking creates a field of molecular ...
  • Chen, Debbie K.; Erb, M. Kelley; Tong, Yunjie; Yu, Yang; Sassaroli, Angelo; Bergethon, Peter R.; Fantini, Sergio (Optical Society of America, 2010-9-16)
    Using non-invasive, near-infrared spectroscopy we have previously reported optical signals measured at or around peripheral nerves in response to their stimulation. Such optical signals featured amplitudes on the order of ...
  • Kim, Noel N; Stankovic, Miljan; Cushman, Tulay T; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
  • Sherawat, Manashi; Tolan, Dean R.; Allen, Karen N. (International Union of Crystallography, 2008-4-19)
    The X-ray crystallographic structure of a dimer variant of fructose-1,6-bisphosphate aldolase demonstrates a stable oligomer that mirrors half of the native tetramer. The presence of product demonstrates that this is an ...
  • Oşan, Remus; Zhu, Liping; Shoham, Shy; Tsien, Joe Z. (Public Library of Science, 2007-5-2)
    Recent advances in large-scale ensemble recordings allow monitoring of activity patterns of several hundreds of neurons in freely behaving animals. The emergence of such high-dimensional datasets poses challenges for the ...
  • Plasterer, Thomas N; Smith, Temple F; Mohr, Scott C (BioMed Central, 2001-06-01)
    BACKGROUND. We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein ...
  • Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)
    Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
  • Stimpson, Kaitlin M.; Song, Ihn Young; Jauch, Anna; Holtgreve-Grez, Heidi; Hayden, Karen E.; Bridger, Joanna M.; Sullivan, Beth A. (Public Library of Science, 2010-8-12)
    Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly ...
  • Yaar, Mina; Eller, Mark S; Panova, Izabela; Kubera, John; Wee, Lee Hng; Cowan, Kenneth H; Gilchrest, Barbara A (BioMed Central, 2007-1-26)
    INTRODUCTION. Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, ...
  • Zhong, Jun; Krawczyk, Sarah A.; Chaerkady, Raghothama; Huang, Hailiang; Goel, Renu; Bader, Joel S.; Wong, G. William; Corkey, Barbara E.; Pandey, Akhilesh (American Chemical Society, 2010-08-14)
    Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although mouse adipogenesis has been studied extensively, limited studies have been conducted to characterize this process in humans. We ...
  • Braverman, Eric R; Chen, Amanda Lih-Chuan; Chen, Thomas JH; Schoolfield, John D; Notaro, Alison; Braverman, Dasha; Kerner, Mallory; Blum, Seth H; Arcuri, Vanessa; Varshavskiy, Michael; Damle, Uma; Downs, B William; Waite, Roger L; Oscar-Berman, Marlene; Giordano, John; Blum, Kenneth (Dove Medical Press, 2010-10-15)
    The goal of this study was to determine if impairments detected by the test of variables of attention (TOVA) may be used to predict early attention complaints and memory impairments accurately in a clinical setting. We ...
  • Grimplet, Jerome; Deluc, Laurent G; Tillett, Richard L; Wheatley, Matthew D; Schlauch, Karen A; Cramer, Grant R; Cushman, John C (BioMed Central, 2007-6-21)
    BACKGROUND: Berries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp ...
  • Lafyatis, Robert; Marshak-Rothstein, Ann (BioMed Central, 2007-11-29)
    A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors ...
  • Deluc, Laurent G; Grimplet, Jérôme; Wheatley, Matthew D; Tillett, Richard L; Quilici, David R; Osborne, Craig; Schooley, David A; Schlauch, Karen A; Cushman, John C; Cramer, Grant R (BioMed Central, 2007-11-22)
    BACKGROUND: Grape berry development is a dynamic process that involves a complex series of molecular genetic and biochemical changes divided into three major phases. During initial berry growth (Phase I), berry size increases ...
  • Shriner, Daniel; Adeyemo, Adebowale; Gerry, Norman P.; Herbert, Alan; Chen, Guanjie; Doumatey, Ayo; Huang, Hanxia; Zhou, Jie; Christman, Michael F.; Rotimi, Charles N. (Public Library of Science, 2009-12-22)
    Human height is the prototypical polygenic quantitative trait. Recently, several genetic variants influencing adult height were identified, primarily in individuals of East Asian (Chinese Han or Korean) or European ancestry. ...
  • Weinger, Ilene; Klepeis, Veronica E.; Trinkaus-Randall, Vickery (Springer Netherlands, 2005-7-29)
    The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ...
  • Stead, Lesley A; Lash, Timothy L; Sobieraj, Jerome E; Chi, Dorcas D; Westrup, Jennifer L; Charlot, Marjory; Blanchard, Rita A; Lee, John C; King, Thomas C; Rosenberg, Carol L (BioMed Central, 2009-3-25)
    INTRODUCTION. We investigated clinical and pathologic features of breast cancers (BC) in an unselected series of patients diagnosed in a tertiary care hospital serving a diverse population. We focused on triple-negative ...
  • Li, Nien-Chen; Lee, Austin; Whitmer, Rachel A; Kivipelto, Miia; Lawler, Elizabeth; Kazis, Lewis E; Wolozin, Benjamin (BMJ Publishing Group Ltd., 2010-1-12)
    Objective To investigate whether angiotensin receptor blockers protect against Alzheimer's disease and dementia or reduce the progression of both diseases. Design Prospective cohort analysis. Setting Administrative database ...
  • Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Lewis, Mark G.; Geisbert, Joan B.; Grolla, Allen; Leung, Anders; Paragas, Jason; Matthias, Lennox; Smith, Mark A.; Jones, Steven M.; Hensley, Lisa E.; Feldmann, Heinz; Jahrling, Peter B. (Public Library of Science Pathogens, 2008-11-28)
    Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over the last decade in ...

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