Browsing Basic Science by Title

OpenBU

Browsing Basic Science by Title

Sort by: Order: Results:

  • Capzb2 Interacts with β-Tubulin to Regulate Growth Cone Morphology and Neurite Outgrowth
    Davis, David A.; Wilson, Meredith H.; Giraud, Jodel; Xie, Zhigang; Tseng, Huang-Chun; England, Cheryl; Herscovitz, Haya; Tsai, Li-Huei; Delalle, Ivana (Public Library of Science, 2009-10-6)
    An actin regulatory protein unexpectedly also controls microtubule polymerization during the formation and maintenance of cellular outgrowths in neurons. Capping protein (CP) is a heterodimer that regulates actin assembly ...
  • CDKN1C/p57kip2 Is a Candidate Tumor Suppressor Gene in Human Breast Cancer
    Larson, Pamela S; Schlechter, Benjamin L; King, Chia-Lin; Yang, Qiong; Glass, Chelsea N; Mack, Charline; Pistey, Robert; de las Morenas, Antonio; Rosenberg, Carol L (BioMed Central, 2008-3-6)
    BACKGROUND. CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast ...
  • Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy
    Ma, Qiangzhong; Wang, Yawen; Lo, Agnes Shuk-Yee; Gomes, Erica M.; Junghans, Richard P. (Hindawi Publishing Corporation, 2010-6-30)
    The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ...
  • The Circadian System Is a Target and Modulator of Prenatal Cocaine Effects
    Shang, Eva H.; Zhdanova, Irina V. (Public Library of Science, 2007-7-11)
    BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ...
  • Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study
    Wu, Yuntao; Yoder, Alyson; Yu, Dongyang; Wang, Weifeng; Liu, Juan; Barrett, Tracey; Wheeler, David; Schlauch, Karen (BioMed Central, 2008-10-17)
    Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ...
  • Cognitive Aging in Zebrafish
    Yu, Lili; Tucci, Valter; Kishi, Shuji; Zhdanova, Irina V. (Public Library of Science, 2006-12-20)
    BACKGROUND. Age-related impairments in cognitive functions represent a growing clinical and social issue. Genetic and behavioral characterization of animal models can provide critical information on the intrinsic and ...
  • Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome
    Allen, Laura B.; White, Kamila S.; Barlow, David H.; Shear, M. Katherine; Gorman, Jack M.; Woods, Scott W. (Springer US, 2009-7-24)
    Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ...
  • COMBREX: A Project to Accelerate the Functional Annotation of Prokaryotic Genomes
    Roberts, Richard J.; Chang, Yi-Chien; Hu, Zhenjun; Rachlin, John N.; Anton, Brian P.; Pokrzywa, Revonda M.; Choi, Han-Pil; Faller, Lina L.; Guleria, Jyotsna; Housman, Genevieve; Klitgord, Niels; Mazumdar, Varun; McGettrick, Mark G.; Osmani, Lais; Swaminathan, Rajeswari; Tao, Kevin R.; Letovsky, Stan; Vitkup, Dennis; Segrè, Daniel; Salzberg, Steven L.; Delisi, Charles; Steffen, Martin; Kasif, Simon (2010-11-20)
    COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ...
  • Comparative Genomic Characterization of Francisella tularensis Strains Belonging to Low and High Virulence Subspecies
    Champion, Mia D.; Zeng, Qiandong; Nix, Eli B.; Nano, Francis E.; Keim, Paul; Kodira, Chinnappa D.; Borowsky, Mark; Young, Sarah; Koehrsen, Michael; Engels, Reinhard; Pearson, Matthew; Howarth, Clint; Larson, Lisa; White, Jared; Alvarado, Lucia; Forsman, Mats; Bearden, Scott W.; Sjöstedt, Anders; Titball, Richard; Michell, Stephen L.; Birren, Bruce; Galagan, James (Public Library of Science Pathogens, 2009-5-29)
    Tularemia is a geographically widespread, severely debilitating, and occasionally lethal disease in humans. It is caused by infection by a gram-negative bacterium, Francisella tularensis. In order to better understand its ...
  • Comparison of Proteomic and Transcriptomic Profiles in the Bronchial Airway Epithelium of Current and Never Smokers
    Steiling, Katrina; Kadar, Aran Y.; Bergerat, Agnes; Flanigon, James; Sridhar, Sriram; Shah, Vishal; Ahmad, Q. Rushdy; Brody, Jerome S.; Lenburg, Marc E.; Steffen, Martin; Spira, Avrum (Public Libary of Science, 2009-4-9)
    BACKGROUND. Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, the impact of smoking on the airway epithelial proteome and its relationship to smoking-related ...
  • A Computational Approach for Deciphering the Organization of Glycosaminoglycans
    Spencer, Jean L.; Bernanke, Joel A.; Buczek-Thomas, Jo Ann; Nugent, Matthew A. (Public Library of Science, 2010-2-23)
    BACKGROUND. Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide ...
  • Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*
    Frank, Christopher L.; Ge, Xuecai; Xie, Zhigang; Zhou, Ying; Tsai, Li-Huei (American Society for Biochemistry and Molecular Biology, 2010-8-19)
    Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated ...
  • Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides
    Dan, Jennifer M.; Wang, Jennifer P.; Lee, Chrono K.; Levitz, Stuart M. (Public Library of Science, 2008-4-30)
    While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC ...
  • Crystal Structure of the P Pilus Rod Subunit PapA
    Verger, Denis; Bullitt, Esther; Hultgren, Scott J; Waksman, Gabriel (Public Library of SciencePathogens, 2007-5-18)
    P pili are important adhesive fibres involved in kidney infection by uropathogenic Escherichia coli strains. P pili are assembled by the conserved chaperone-usher pathway, which involves the PapD chaperone and the PapC ...
  • Cytokine Reduction in the Treatment of Joint Conditions
    Sipe, J. D.; Martel-Pelletier, J.; Otterness, I. G.; Pelletier, J.-P. (Hindawi Publishing Corporation, 1994)
    The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions ...
  • Developmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementia
    Meck, Warren H.; Williams, Christina L.; Cermak, Jennifer Marie; Blusztajn, Jan Krzysztof (Frontiers Research Foundation, 2008-05-03)
    In order to determine brain and behavioral sensitivity of nutrients that may serve as inductive signals during early development, we altered choline availability to rats during 7 time frames spanning embryonic day (ED) 6 ...
  • Development of Admixture Mapping Panels for African Americans from Commercial High-Density SNP Arrays
    Chen, Guanjie; Shriner, Daniel; Zhou, Jie; Doumatey, Ayo; Huang, Hanxia; Gerry, Norman P; Herbert, Alan; Christman, Michael F; Chen, Yuanxiu; Dunston, Georgia M; Faruque, Mezbah U; Rotimi, Charles N; Adeyemo, Adebowale (BioMed Central, 2010-7-5)
    BACKGROUND: Admixture mapping is a powerful approach for identifying genetic variants involved in human disease that exploits the unique genomic structure in recently admixed populations. To use existing published panels ...
  • Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection
    Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Hickey, Andrew C.; Smith, Mark A.; Chan, Yee-Peng; Wang, Lin-Fa; Mattapallil, Joseph J.; Geisbert, Joan B.; Bossart, Katharine N.; Broder, Christopher C. (Public Library of Science, 2010-5-18)
    Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent ...
  • Diffuse Optical Signals in Response to Peripheral Nerve Stimulation Reflect Skeletal Muscle Kinematics
    Erb, M. Kelley; Chen, Debbie K.; Sassaroli, Angelo; Fantini, Sergio; Bergethon, Peter R. (Optical Society of America, 2010-9-16)
    Previously we have reported a near-infrared optical response in the region occupied by a peripheral nerve that is distal to the site of electrical stimulation of that peripheral nerve. This "intermediate" signal is vascular ...
  • Direct Inhibition of T-Cell Responses by the Cryptococcus Capsular Polysaccharide Glucuronoxylomannan
    Yauch, Lauren E; Lam, Jennifer S; Levitz, Stuart M (Public Library of Science PathogensPublic Library of Science, 2006-11-10)
    The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high-molecular-weight polysaccharide that is shed ...

Search OpenBU


Advanced Search

Browse

Deposit Materials