Browsing Clinical Science by Title

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Browsing Clinical Science by Title

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  • Latourelle, Jeanne C; Dybdahl, Merete; Destefano, Anita L; Myers, Richard H; Lash, Timothy L (Dove Medical Press, 2010-8-9)
    PURPOSE: Estrogen exposure has been associated with the occurrence of Parkinson's disease (PD), as well as many other disorders, and yet the mechanisms underlying these relations are often unknown. While it is likely that ...
  • Elliott, Katherine S.; Zeggini, Eleftheria; McCarthy, Mark I.; Gudmundsson, Julius; Sulem, Patrick; Stacey, Simon N.; Thorlacius, Steinunn; Amundadottir, Laufey; Grönberg, Henrik; Xu, Jianfeng; Gaborieau, Valerie; Eeles, Rosalind A.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Muir, Kenneth; Hwang, Shih-Jen; Spitz, Margaret R.; Zanke, Brent; Carvajal-Carmona, Luis; Brown, Kevin M.; Mann, Graham J.; Hayward, Nicholas K.; Macgregor, Stuart; Tomlinson, Ian P. M.; Lemire, Mathieu; Amos, Christopher I.; Murabito, Joanne M.; Isaacs, William B.; Easton, Douglas F.; Brennan, Paul; Barkardottir, Rosa B.; Gudbjartsson, Daniel F.; Rafnar, Thorunn; Hunter, David J.; Chanock, Stephen J.; Stefansson, Kari; Ioannidis, John P. A.; Hopper, John L.; Aitken, Joanne F.; Kefford, Richard F.; Giles, Graham G.; Armstrong, Bruce K. (Public Library of Science, 2010-5-28)
    BACKGROUND. Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may ...
  • Goetz, Matthew Bidwell; Hoang, Tuyen; Henry, S. Randal; Knapp, Herschel; Anaya, Henry D.; Gifford, Allen L.; Asch, Steven M. (Springer-Verlag, 2009-10-2)
    BACKGROUND Sustainability—the routinization and institutionalization of processes that improve the quality of healthcare—is difficult to achieve and not often studied. OBJECTIVE To evaluate the sustainability of increased ...
  • Laramie, Jason M; Wilk, Jemma B; Hunt, Steven C; Ellison, R Curtis; Chakravarti, Aravinda; Boerwinkle, Eric; Myers, Richard H (BioMed Central, 2006-3-1)
    BACKGROUND: Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several ...
  • Gardiner, Paula; Buettner, Catherine; Davis, Roger B; Phillips, Russell S; Kemper, Kathi J (BioMed Central, 2008-3-31)
    BACKGROUND. Little is known about the prevalence of dietary supplement (DS) use in American adolescents. We conducted this study to analyze the prevalence of DS use and factors associated with this use in a national ...
  • Gardiner, Paula; Kemper, Kathi J; Legedza, Anna; Phillips, Russell S (BioMed Central, 2007-11-30)
    BACKGROUND. Little is known about the association between use of herbs and dietary supplements (HDS) and lifestyle/behavior factors in young adults in the US. METHODS. Analyzing the 2002 National Health Interview Survey ...
  • Wyszynski, Diego F; Nolan, Vikki G (BioMed Central, 2004-5-12)
    BACKGROUND. The purpose of this study was to determine whether the National Health Interview Survey is a useful source to identify informative families for genetic studies of birth defects. METHODS. The 1994/1995 National ...
  • Lightner, Amy; Schust, Danny J.; Chen, Yi-Bin A.; Barrier, Breton F. (Hindawi Publishing Corporation, 2008-7-6)
    Human pregnancy poses a fundamental immunological problem because the placenta and fetus are genetically different from the host mother. Classical transplantation theory has not provided a plausible solution to this problem. ...
  • Krieg, Thomas; Abraham, David; Lafyatis, Robert (BioMed Central, 2007-8-15)
    Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). Experimental studies suggest that a complex network ...
  • Lipner, Ettie M.; Law, Melissa A.; Barnett, Elizabeth; Keystone, Jay S.; von Sonnenburg, Frank; Loutan, Louis; Prevots, D. Rebecca; Klion, Amy D.; Nutman, Thomas B. (Public Library of Science, 2007-12-26)
    BACKGROUND. As international travel increases, there is rising exposure to many pathogens not traditionally encountered in the resource-rich countries of the world. Filarial infections, a great problem throughout the ...
  • Cho, Michael H; Klanderman, Barbara J; Litonjua, Augusto A; Sparrow, David; Silverman, Edwin K; Raby, Benjamin A (BioMed Central, 2008-12-30)
    BACKGROUND: Rare loss-of-function folliculin (FLCN) mutations are the genetic cause of Birt-Hogg-Dubé syndrome, a monogenic disorder characterized by spontaneous pneumothorax, fibrofolliculomas, and kidney tumors. ...
  • Alikhani, Mani; Roy, Sayon; Graves, Dana T. (Molecular Vision, 2010-3-10)
    PURPOSE. An early and significant event in diabetic retinopathy is the loss of retinal microvascular pericytes. Studies were performed to investigate pathways through which an advanced glycation endproduct and tumor necrosis ...
  • Behl, Yugal; Krothapalli, Padmaja; Desta, Tesfahun; Roy, Sayon; Graves, Dana T. (American Diabetes Association, 2009-1-23)
    OBJECTIVE: To investigate early events leading to microvascular cell loss in diabetic retinopathy. RESEARCH DESIGN AND METHODS: FOXO1 was tested in vivo by DNA binding activity and by nuclear translocation in microvascular ...
  • Levy, Daniel; Larson, Martin G; Benjamin, Emelia J; Newton-Cheh, Christopher; Wang, Thomas J; Hwang, Shih-Jen; Vasan, Ramachandran S; Mitchell, Gary F (BioMed Central, 2007-9-19)
    BACKGROUND: About one quarter of adults are hypertensive and high blood pressure carries increased risk for heart disease, stroke, kidney disease and death. Increased arterial stiffness is a key factor in the pathogenesis ...
  • Larson, Martin G; Atwood, Larry D; Benjamin, Emelia J; Cupples, L Adrienne; D'Agostino, Ralph B; Fox, Caroline S; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Murabito, Joanne M; Newton-Cheh, Christopher; O'Donnell, Christopher J; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Thomas J; Wolf, Philip A; Levy, Daniel (BioMed Central, 2007-9-19)
    BACKGROUND: Cardiovascular disease (CVD) and its most common manifestations – including coronary heart disease (CHD), stroke, heart failure (HF), and atrial fibrillation (AF) – are major causes of morbidity and mortality. ...
  • Cupples, L Adrienne; Arruda, Heather T; Benjamin, Emelia J; D'Agostino, Ralph B; Demissie, Serkalem; DeStefano, Anita L; Dupuis, Josée; Falls, Kathleen M; Fox, Caroline S; Gottlieb, Daniel J; Govindaraju, Diddahally R; Guo, Chao-Yu; Heard-Costa, Nancy L; Hwang, Shih-Jen; Kathiresan, Sekar; Kiel, Douglas P; Laramie, Jason M; Larson, Martin G; Levy, Daniel; Liu, Chun-Yu; Lunetta, Kathryn L; Mailman, Matthew D; Manning, Alisa K; Meigs, James B; Murabito, Joanne M; Newton-Cheh, Christopher; O'Connor, George T; O'Donnell, Christopher J; Pandey, Mona; Seshadri, Sudha; Vasan, Ramachandran S; Wang, Zhen Y; Wilk, Jemma B; Wolf, Philip A; Yang, Qiong; Atwood, Larry D (BioMed Central, 2007-9-19)
    BACKGROUND: The Framingham Heart Study (FHS), founded in 1948 to examine the epidemiology of cardiovascular disease, is among the most comprehensively characterized multi-generational studies in the world. Many collected ...
  • Wilk, Jemma B; Walter, Robert E; Laramie, Jason M; Gottlieb, Daniel J; O'Connor, George T (BioMed Central, 2007-9-19)
    BACKGROUND: Pulmonary function measures obtained by spirometry are used to diagnose chronic obstructive pulmonary disease (COPD) and are highly heritable. We conducted genome-wide association (GWA) analyses (Affymetrix ...
  • Sipilanyambe, Naawa; Simon, Jonathon L; Chanda, Pascalina; Olumese, Peter; Snow, Robert W; Hamer, Davidson H (BioMed Central, 2008-1-29)
    BACKGROUND Following the recognition that morbidity and mortality due to malaria had dramatically increased in the last three decades, in 2002 the government of Zambia reviewed its efforts to prevent and treat malaria. ...
  • Oscar-Berman, Marlene; Valmas, Mary M; Sawyer, Kayle S; Kirkley, Shalene M; Gansler, David A; Merritt, Diane; Couture, Ashley (Dove Medical Press, 2009-06-10)
    Alcoholism and antisocial personality disorder (ASPD) often are comorbid conditions. Alcoholics, as well as nonalcoholic individuals with ASPD, exhibit behaviors associated with prefrontal brain dysfunction such as increased ...
  • Jette, Alan M; McDonough, Christine M; Ni, Pengsheng; Haley, Stephen M; Hambleton, Ronald K; Olarsch, Sippy; Hunter, David J; Kim, Young-jo; Felson, David T (BioMed Central, 2009-7-9)
    INTRODUCTION. The objectives of this study were to develop a functional outcome instrument for hip and knee osteoarthritis research (OA-FUNCTION-CAT) using item response theory (IRT) and computer adaptive test (CAT) methods ...

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