Browsing Clinical Science by Title

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Browsing Clinical Science by Title

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  • Kiel, Douglas P; Demissie, Serkalem; Dupuis, Josée; Lunetta, Kathryn L; Murabito, Joanne M; Karasik, David (BioMed Central, 2007-9-19)
    BACKGROUND: Osteoporosis is characterized by low bone mass and compromised bone structure, heritable traits that contribute to fracture risk. There have been no genome-wide association and linkage studies for these traits ...
  • Benjamin, Emelia J; Dupuis, Josée; Larson, Martin G; Lunetta, Kathryn L; Booth, Sarah L; Govindaraju, Diddahally R; Kathiresan, Sekar; Keaney, John F; Keyes, Michelle J; Lin, Jing-Ping; Meigs, James B; Robins, Sander J; Rong, Jian; Schnabel, Renate; Vita, Joseph A; Wang, Thomas J; Wilson, Peter WF; Wolf, Philip A; Vasan, Ramachandran S (BioMed Central, 2007-9-19)
    BACKGROUND: Systemic biomarkers provide insights into disease pathogenesis, diagnosis, and risk stratification. Many systemic biomarker concentrations are heritable phenotypes. Genome-wide association studies (GWAS) provide ...
  • Ma, Qianli; Yu, Yi; Meng, Yan; Farrell, John; Farrer, Lindsay A; Wilcox, Marsha A (BioMed Central, 2005-12-30)
    Both theoretical and applied studies have proven that the utility of single nucleotide polymorphism (SNP) markers in linkage analysis is more powerful and cost-effective than current microsatellite marker assays. Here we ...
  • Wyszynski, Diego F; Panhuysen, Carolien I; Ma, Qianli; Yip, Agustin G; Wilcox, Marsha; Erlich, Porat; Farrer, Lindsay A (BioMed Central, 2003-12-31)
    BACKGROUND. To find specific genes predisposing to heavy alcohol consumption (self-reported consumption of 24 grams or more of alcohol per day among men and 12 grams or more among women), we studied 330 families collected ...
  • Li, Jian-Liang; Hayden, Michael R; Warby, Simon C; Durr, Alexandra; Morrison, Patrick J; Nance, Martha; Ross, Christopher A; Margolis, Russell L; Rosenblatt, Adam; Squitieri, Ferdinando; Frati, Luigi; Gómez-Tortosa, Estrella; García, Carmen Ayuso; Suchowersky, Oksana; Klimek, Mary Lou; Trent, Ronald JA; McCusker, Elizabeth; Novelletto, Andrea; Frontali, Marina; Paulsen, Jane S; Jones, Randi; Ashizawa, Tetsuo; Lazzarini, Alice; Wheeler, Vanessa C; Prakash, Ranjana; Xu, Gang; Djoussé, Luc; Mysore, Jayalakshmi Srinidhi; Gillis, Tammy; Hakky, Michael; Cupples, L Adrienne; Saint-Hilaire, Marie H; Cha, Jang-Ho J; Hersch, Steven M; Penney, John B; Harrison, Madaline B; Perlman, Susan L; Zanko, Andrea; Abramson, Ruth K; Lechich, Anthony J; Duckett, Ayana; Marder, Karen; Conneally, P Michael; Gusella, James F; MacDonald, Marcy E; Myers, Richard H (BioMed Central, 2006-8-17)
    BACKGROUND: Age at onset of Huntington's disease (HD) is correlated with the size of the abnormal CAG repeat expansion in the HD gene; however, several studies have indicated that other genetic factors also contribute to ...
  • Brahmbhatt, Jamin V; Liou, Louis S (BioMed Central, 2008-1-29)
    INTRODUCTION Giant prostatic adenocarcinoma represents a rare and challenging treatment dilemma. CASE PRESENTATION We describe a case of an otherwise healthy 71-year-old African male who presented with a PSA of 5800 ng/ml ...
  • Waning, Brenda; Diedrichsen, Ellen; Jambert, Elodie; Bärnighausen, Till; Li, Yun; Pouw, Mieke; Moon, Suerie (BioMed Central, 2010-10-17)
    BACKGROUND: Important advances in the development and production of quality-certified pediatric antiretroviral (ARV) formulations have recently been made despite significant market disincentives for manufacturers. This ...
  • Latourelle, Jeanne C; Sun, Mei; Lew, Mark F; Suchowersky, Oksana; Klein, Christine; Golbe, Lawrence I; Mark, Margery H; Growdon, John H; Wooten, G Frederick; Watts, Ray L; Guttman, Mark; Racette, Brad A; Perlmutter, Joel S; Ahmed, Anwar; Shill, Holly A; Singer, Carlos; Goldwurm, Stefano; Pezzoli, Gianni; Zini, Michela; Saint-Hilaire, Marie H; Hendricks, Audrey E; Williamson, Sally; Nagle, Michael W; Wilk, Jemma B; Massood, Tiffany; Huskey, Karen W; Laramie, Jason M; DeStefano, Anita L; Baker, Kenneth B; Itin, Ilia; Litvan, Irene; Nicholson, Garth; Corbett, Alastair; Nance, Martha; Drasby, Edward; Isaacson, Stuart; Burn, David J; Chinnery, Patrick F; Pramstaller, Peter P; Al-hinti, Jomana; Moller, Anette T; Ostergaard, Karen; Sherman, Scott J; Roxburgh, Richard; Snow, Barry; Slevin, John T; Cambi, Franca; Gusella, James F; Myers, Richard H (BioMed Central, 2008-11-5)
    BACKGROUND: We report age-dependent penetrance estimates for leucine-rich repeat kinase 2 (LRRK2)-related Parkinson's disease (PD) in a large sample of familial PD. The most frequently seen LRRK2 mutation, Gly2019Ser ...
  • Zhao, Yang; Kuo, Tzu-Chun; Weir, Sharada; Kramer, Marilyn S; Ash, Arlene S (BioMed Central, 2008-5-22)
    BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder incurring significant social and economic costs. This study uses a US administrative claims database to evaluate the effect of AD on direct healthcare ...
  • Zhang, Aimin; Park, Sung Kyun; Wright, Robert O.; Weisskopf, Marc G.; Mukherjee, Bhramar; Nie, Huiling; Sparrow, David; Hu, Howard (National Institute of Environmental Health Sciences, 2010-09)
    BACKGROUND. Cumulative lead exposure is associated with a widened pulse pressure (PP; the difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. ...
  • Sebastiani, Paola; Zhao, Zhenming; Abad-Grau, Maria M; Riva, Alberto; Hartley, Stephen W; Sedgewick, Amanda E; Doria, Alessandro; Montano, Monty; Melista, Efthymia; Terry, Dellara; Perls, Thomas T; Steinberg, Martin H; Baldwin, Clinton T (BioMed Central, 2008-1-14)
    BACKGROUND: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. RESULTS. We present a ...
  • Wharam, J. Frank; Paasche-Orlow, Michael K.; Farber, Neil J.; Sinsky, Christine; Rucker, Lisa; Rask, Kimberly J.; Figaro, M. Kathleen; Braddock, Clarence; Barry, Michael J.; Sulmasy, Daniel P. (Springer-Verlag, 2009-3-18)
    BACKGROUND Pay-for-performance is proliferating, yet its impact on key stakeholders remains uncertain. OBJECTIVE The Society of General Internal Medicine systematically evaluated ethical issues raised by performance-based ...
  • D'Jaen, Gabriela; Pantanowitz, Liron; Bower, Mark; Buskin, Susan; Neil, Nancy; Greco, Erin; Cooley, Timothy; Henry, David; Stem, Jonathan; Dezube, Bruce; Stebbing, Justin; Aboulafia, David (BioMed Central, 2010-10-11)
  • Chaudhry, Harman; Mundi, Raman; Singh, Ishu; Einhorn, Thomas A.; Bhandari, Mohit (Medknow Publications, 2008-04)
    Randomized trials constitute approximately 3% of the orthopaedic literature Concerns regarding quality of the orthopaedic literature stem from a widespread notion that the overall quality of the surgical literature is in ...
  • Xu, Chong; Politch, Joseph A; Mayer, Kenneth H; Anderson, Deborah J (BioMed Central, 2005-10-11)
    BACKGROUND. Episomal 2-long terminal repeat (LTR) HIV-1 cDNA, a by-product of HIV-1 infection, is used in clinical trials as a marker for ongoing viral replication. It would be useful to employ 2-LTR cDNA to monitor cryptic ...
  • Dalgin, Gul S.; Holloway, Dustin T.; Liou, Louis S.; DeLisi, Charles (Libertas Academica, 2007-2-9)
    Microarray gene expression profiling has been used to distinguish histological subtypes of renal cell carcinoma (RCC), and consequently to identify specific tumor markers. The analytical procedures currently in use find ...
  • Katz, Ralph V; Jean-Charles, Germain; Green, B Lee; Kressin, Nancy R; Claudio, Cristina; Wang, MinQi; Russell, Stefanie L; Outlaw, Jason (BioMed Central, 2009-12-16)
    BACKGROUND. This analysis assessed whether Blacks, Whites and Puerto-Rican (PR) Hispanics differed in their ability to identify the Tuskegee Syphilis Study (TSS) via open-ended questions following lead-in recognition and ...
  • Shaik-Dasthagirisaheb, Yazdani B; Kantarci, Alpdogan; Gibson, Frank C (BioMed Central, 2010-11-29)
    Periodontal disease is a chronic inflammatory gum disease that in severe cases leads to tooth loss. Porphyromonas gingivalis (Pg) is a bacterium closely associated with generalized forms of periodontal disease. Clinical ...
  • Guo, Chao-Yu; Cui, Jing; Cupples, L Adrienne (BioMed Central, 2005-12-30)
    The transmission/disequilibrium test was introduced to test for linkage disequilibrium between a marker and a putative disease locus using case-parent trios. However, parental genotypes may be incomplete in such a study. ...
  • Mahon, Barbara E; Shea, Kimberly M; Dougherty, Nancy N; Loughlin, Anita M (BioMed Central, 2008-5-14)
    BACKGROUND. Population-based electronic immunization registries create the possibility of using registry data to conduct vaccine effectiveness studies which could have methodological advantages over traditional observational ...

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