Browsing Department of Biochemistry by Title

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Browsing Department of Biochemistry by Title

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  • Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia
    Baron, Rebecca M.; Lopez-Guzman, Silvia; Riascos, Dario F.; Macias, Alvaro A.; Layne, Matthew D.; Cheng, Guiying; Harris, Cailin; Chung, Su Wol; Reeves, Raymond; von Andrian, Ulrich H.; Perrella, Mark A. (Public Library of Science, 2010-5-14)
    BACKGROUND. The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes ("enhanceosomes") that upregulate expression of select ...
  • Effects of Tamoxifen on Vaginal Blood Flow and Epithelial Morphology in the Rat
    Kim, Noel N; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T; Goldstein, Irwin; Traish, Abdulmaged M (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer
    Chatterjee, Aparajita; Carpentieri, Andrea; Ratner, Daniel M.; Bullitt, Esther; Costello, Catherine E.; Robbins, Phillips W.; Samuelson, John (Public Library of Science, 2010-8-19)
    The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or G. duodenalis) is the cyst. The Giardia cyst wall contains fibrils of a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer ...
  • Hematopoietic Gene Promoters Subjected to a Group-Combinatorial Study of DNA Samples: Identification of a Megakaryocytic Selective DNA Signature
    Hazony, Yehonathan; Lu, Jun; St. Hilaire, Cynthia; Ravid, Katya (Oxford University Press, 2006-08-26)
    Identification of common sub-sequences for a group of functionally related DNA sequences can shed light on the role of such elements in cell-specific gene expression. In the megakaryocytic lineage, no one single unique ...
  • Immunodetection of nmt55/p54nrb Isoforms in Human Breast Cancer
    Pavao, Matthew; Huang, Yue-Hua; Hafer, Laurie J; Moreland, Robert B; Traish, Abdulmaged M (BioMed Central, 2001-10-29)
    BACKGROUND. We previously identified and characterized a novel 55 kDa nuclear protein, termed nmt55/p54nrb, whose expression was decreased in a subset of human breast tumors. The objective of this study was to determine ...
  • Inhibition of Influenza M2-Induced Cell Death Alleviates Its Negative Contribution to Vaccination Efficiency
    Ilyinskii, Petr O.; Gambaryan, Alexandra S.; Meriin, Anatoli B.; Gabai, Vladimir; Kartashov, Alex; Thoidis, Galini; Shneider, Alexander M. (Public Library of Science, 2008-1-16)
    The effectiveness of recombinant vaccines encoding full-length M2 protein of influenza virus or its ectodomain (M2e) have previously been tested in a number of models with varying degrees of success. Recently, we reported ...
  • Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77
    Chao, Lily C.; Wroblewski, Kevin; Zhang, Zidong; Pei, Liming; Vergnes, Laurent; Ilkayeva, Olga R.; Ding, Shi Ying; Reue, Karen; Watt, Matthew J.; Newgard, Christopher B.; Pilch, Paul F.; Hevener, Andrea L.; Tontonoz, Peter (American Diabetes Association, 2009-9-9)
    OBJECTIVE: Nur77 is an orphan nuclear receptor with pleotropic functions. Previous studies have identified Nur77 as a transcriptional regulator of glucose utilization genes in skeletal muscle and gluconeogenesis in liver. ...
  • Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens
    Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.; Lerner, Adam (Molecular Vision, 2009-4-03)
    PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ...
  • Mechanisms in Bradykinin Stimulated Arachidonate Release and Synthesis of Prostaglandin and Platelet Activating Factor
    Ricupero, D.; Taylor, L.; Tlucko, A.; Navarro, J.; Polgar, P. (Hindawi Publishing Corporation, 1982)
    Regulatory mechanisms in bradykinin (BK) activated release of arachidonate (ARA) and synthesis of prostaglandin (PG) and platelet activating factor (PAF) were studied in bovine pulmonary artery endothelial cells (BPAEC). ...
  • MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes
    Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Gygi, Steven P.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G. (The Rockefeller University Press, 2009-06-22)
    Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now ...
  • Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein
    Zerbinatti, Celina V; Cordy, Joanna M; Chen, Ci-Di; Guillily, Maria; Suon, Sokreine; Ray, William J; Seabrook, Guy R; Abraham, Carmela R; Wolozin, Benjamin (BioMed Central, 2008-3-18)
    BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ...
  • A p130Cas Tyrosine Phosphorylated Substrate Domain Decoy Disrupts v-Crk Signaling
    Kirsch, Kathrin H; Kensinger, Margaret; Hanafusa, Hidesaburo; August, Avery (BioMed Central, 2002-7-15)
    BACKGROUND. The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. This protein has a substrate domain with up to 15 tyrosines ...
  • The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia
    Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K (Public Library of Science, 2008-6-24)
    BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified a ...
  • Streptozotocin-Induced Diabetes in the Rat Is Associated with Changes in Vaginal Hemodynamics, Morphology and Biochemical Markers
    Kim, Noel N; Stankovic, Miljan; Cushman, Tulay T; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
  • Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
    Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)
    Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
  • Temporal Profiling of the Secretome during Adipogenesis in Humans
    Zhong, Jun; Krawczyk, Sarah A.; Chaerkady, Raghothama; Huang, Hailiang; Goel, Renu; Bader, Joel S.; Wong, G. William; Corkey, Barbara E.; Pandey, Akhilesh (American Chemical Society, 2010-08-14)
    Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although mouse adipogenesis has been studied extensively, limited studies have been conducted to characterize this process in humans. We ...
  • Tri-Nucleotide Receptors Play a Critical Role in Epithelial Cell Wound Repair
    Weinger, Ilene; Klepeis, Veronica E.; Trinkaus-Randall, Vickery (Springer Netherlands, 2005-7-29)
    The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ...

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