Browsing Department of Biochemistry by Title

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Browsing Department of Biochemistry by Title

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  • Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein
    Zerbinatti, Celina V; Cordy, Joanna M; Chen, Ci-Di; Guillily, Maria; Suon, Sokreine; Ray, William J; Seabrook, Guy R; Abraham, Carmela R; Wolozin, Benjamin (BioMed Central, 2008-3-18)
    BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ...
  • A p130Cas Tyrosine Phosphorylated Substrate Domain Decoy Disrupts v-Crk Signaling
    Kirsch, Kathrin H; Kensinger, Margaret; Hanafusa, Hidesaburo; August, Avery (BioMed Central, 2002-7-15)
    BACKGROUND. The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. This protein has a substrate domain with up to 15 tyrosines ...
  • The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia
    Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K (Public Library of Science, 2008-6-24)
    BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified a ...
  • Streptozotocin-Induced Diabetes in the Rat Is Associated with Changes in Vaginal Hemodynamics, Morphology and Biochemical Markers
    Kim, Noel N; Stankovic, Miljan; Cushman, Tulay T; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
  • Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
    Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)
    Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
  • Temporal Profiling of the Secretome during Adipogenesis in Humans
    Zhong, Jun; Krawczyk, Sarah A.; Chaerkady, Raghothama; Huang, Hailiang; Goel, Renu; Bader, Joel S.; Wong, G. William; Corkey, Barbara E.; Pandey, Akhilesh (American Chemical Society, 2010-08-14)
    Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although mouse adipogenesis has been studied extensively, limited studies have been conducted to characterize this process in humans. We ...
  • Tri-Nucleotide Receptors Play a Critical Role in Epithelial Cell Wound Repair
    Weinger, Ilene; Klepeis, Veronica E.; Trinkaus-Randall, Vickery (Springer Netherlands, 2005-7-29)
    The cornea plays a major role in the refraction of light to the retina. Therefore, the integrity and transparency of the corneal epithelium are critical to vision. Following injury, a combination of rapid signal transduction ...

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